Altered long-range alpha-band synchronization during visual short-term memory retention in children born very preterm.
Altered long-range alpha-band synchronization during visual short-term memory retention in children born very preterm.
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DOI：
10.1016/j.neuroimage.2010.10.044
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Grunau RE
中科院分区：
文献类型：
--
作者：
Doesburg SM;Ribary U;Herdman AT;Miller SP;Poskitt KJ;Moiseev A;Whitfield MF;Synnes A;Grunau RE
早产儿，即使智力基本正常，也经常在执行功能和视觉空间处理方面遇到选择性困难。在这一组中，结构性皮层连接的发展被认为是改变的，功能性磁共振成像（fMRI）证据表明，极早产儿在认知过程中招募不同模式的皮层区域之间的功能连接。跨脑区的神经振荡同步已被提出作为一种机制，动态分配功能耦合，以支持感知和认知处理，但很少有人知道振荡同步可能发挥什么作用，在改变神经认知发展的早产儿。为了研究这一点，我们记录了脑磁图（MEG）活动，而7-8岁的早产儿和年龄匹配的足月对照组进行了视觉短期记忆任务。非常早产儿表现出减少的长程同步在视觉短期记忆保留的α-波段，表明皮质α节律可能发挥了关键作用，在改变模式的功能连接，这一人口在认知和感知过程中表示。长距离α-波段同步也与任务表现和视觉感知能力非常早产组内，表明改变α振荡机制介导短暂的功能整合皮质区域之间可能是相关的选择性问题，在这个脆弱的人群在学龄期的神经认知发展。
Children born very preterm, even when intelligence is broadly normal, often experience selective difficulties in executive function and visual-spatial processing. Development of structural cortical connectivity is known to be altered in this group, and functional magnetic resonance imaging (fMRI) evidence indicates that very preterm children recruit different patterns of functional connectivity between cortical regions during cognition. Synchronization of neural oscillations across brain areas has been proposed as a mechanism for dynamically assigning functional coupling to support perceptual and cognitive processing, but little is known about what role oscillatory synchronization may play in the altered neurocognitive development of very preterm children. To investigate this, we recorded magnetoencephalographic (MEG) activity while 7–8 year old children born very preterm and age matched full-term controls performed a visual short-term memory task. Very preterm children exhibited reduced long-range synchronization in the alpha-band during visual short-term memory retention, indicating that cortical alpha rhythms may play a critical role in altered patterns functional connectivity expressed by this population during cognitive and perceptual processing. Long-range alpha-band synchronization was also correlated with task performance and visual-perceptual ability within the very preterm group, indicating that altered alpha-oscillatory mechanisms mediating transient functional integration between cortical regions may be relevant to selective problems in neurocognitive development in this vulnerable population at school age.
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影响因子：
4.7
作者：
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通讯作者：
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DOI：
10.1017/s1355617708080053
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