Heterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study.
Heterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study.
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DOI：
10.1016/j.joca.2022.02.614
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发表时间：
2022-05
影响因子：
7
通讯作者：
Guermazi, A.
中科院分区：
文献类型：
--
作者：
Roemer, F. W.;Felson, D. T.;Stefanik, J. J.;Rabasa, G.;Wang, N.;Crema, M. D.;Neogi, T.;Nevitt, M. C.;Torner, J.;Lewis, C. E.;Peloquin, C.;Guermazi, A.
Eligibility for clinical trials in osteoarthritis (OA) is usually limited to Kellgren-Lawrence (KL) grades 2 and 3 knees. Our aim was to describe the prevalence and severity of cartilage damage in KL 2 and 3 knees by compartment and articular subregion. The Multicenter Osteoarthritis (MOST) study is a cohort study of individuals with or at risk for knee OA. All baseline MRIs with radiographic disease severity KL2 and 3 were included. Knee MRIs were read for cartilage damage in 14 subregions. We determined the frequencies of no, any and widespread full-thickness cartilage damage by knee compartment, and the prevalence of any cartilage damage in 14 articular subregions. 665 knees from 665 participants were included (mean age 63.8 ± 7.9 years, 66.5% women). 372 knees were KL2 and 293 knees were KL3. There was no cartilage damage in 78 (21.0%) medial tibio-femoral joint (TFJ), 157 (42.2%) lateral TFJ and 62 (16.7%) patello-femoral joint (PFJ) compartments of KL2 knees, and 17 (5.8%), 115 (39.3%) and 35 (12.0%) compartments, respectively, of KL3 knees. There was widespread full-thickness damage in 94 (25.3%) medial TFJ, 36 (9.7%) lateral TFJ and 176 (47.3%) PFJ compartments of KL2 knees, and 217 (74.1%), 70 (23.9%) and 104 (35.5%) compartments, respectively, of KL3 knees. The subregions most likely to have any damage were central medial femur (80.5%), medial patella (69.8%) and central medial tibia (69.9). KL2 and KL3 knees vary greatly in cartilage morphology. Heterogeneity in the prevalence, severity and location of cartilage damage in in KL2 and 3 knees should be considered when planning disease modifying trials for knee OA.
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影响因子：
27.4
作者：
Eckstein, F.;Le Graverand, M. P. Hellio;Buck, R.
通讯作者：
Buck, R.
影响因子：
7
作者：
Felson, D. T.;Niu, J.;Nevitt, M. C.
通讯作者：
Nevitt, M. C.
DOI：
10.1038/s41584-018-0010-z
发表时间：
2018-06
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
Roemer FW;Kwoh CK;Hayashi D;Felson DT;Guermazi A
通讯作者：
Guermazi A
影响因子：
39.2
作者：
Felson, DT;Chaisson, CE;Gale, DR
通讯作者：
Gale, DR
影响因子：
--
作者：
Felson, David T.;Niu, Jingbo;Aliabadi, Piran
通讯作者：
Aliabadi, Piran