Angiotensin type 2 receptors: blood pressure regulation and end organ damage.
Angiotensin type 2 receptors: blood pressure regulation and end organ damage.
复制标题
DOI：
10.1016/j.coph.2015.01.004
复制
发表时间：
2015-04
影响因子：
4
通讯作者：
Steckelings, Ulrike Muscha
中科院分区：
文献类型：
--
作者：
Sumners, Colin;de Kloet, Annette D.;Krause, Eric G.;Unger, Thomas;Steckelings, Ulrike Muscha
In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future anti-hypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.
登录
查看更多内容
影响因子：
4.7
作者：
Joseph JP;Mecca AP;Regenhardt RW;Bennion DM;Rodríguez V;Desland F;Patel NA;Pioquinto DJ;Unger T;Katovich MJ;Steckelings UM;Sumners C
通讯作者：
Sumners C
影响因子：
64.8
作者：
ICHIKI, T;LABOSKY, PA;INAGAMI, T
通讯作者：
INAGAMI, T
影响因子：
13.5
作者：
Jones ES;Vinh A;McCarthy CA;Gaspari TA;Widdop RE
通讯作者：
Widdop RE
DOI：
10.1523/jneurosci.6262-11.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Capone C;Faraco G;Peterson JR;Coleman C;Anrather J;Milner TA;Pickel VM;Davisson RL;Iadecola C
通讯作者：
Iadecola C
影响因子：
4
作者：
Gao, Lie;Zucker, Irving H.
通讯作者：
Zucker, Irving H.