Genetic analysis of Streptococcus mutans virulence.

Genetic analysis of Streptococcus mutans virulence.
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变形链球菌毒力的遗传分析。

DOI:
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发表时间:
1985
影响因子:
--
通讯作者:
R. Curtiss
R. Curtiss
中科院分区:
医学3区
文献类型:
--
作者:
R. Curtiss

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Clarke(1924)首先从人类龋齿病变中分离和描述了一种链球菌,并推测它是一种潜在的龋病病原体。他将这种有机体命名为变形链球菌。这一观察被忽视了大约35年,直到Orland(1959)证明肠球菌可以导致无菌大鼠的龋齿,以及Fitzgerald及其同事(Fitzgerald和Kyes 1960;Fitzgerald等人)。1960年)发现,在无菌动物中,在感染克拉克最初描述的那种类型的链球菌后,观察到最大的致龋性。后来证明,变形链球菌是人类龋齿的主要病原体(见NEWBRUN 1978)。变形链球菌只有在生命的第一年牙齿萌发后才会在人类身上定居,大多数人类在童年早期就会被殖民(Siles等人。1976年)。
CLARKE (1924) first isolated and described a streptococcus from a human carious lesion and inferred that it was a potential causative agent of dental caries. He named the organism Streptococcus mutans. This observation went unnoticed for some 35 years until ORLAND (1959) demonstrated that enterococci could cause dental caries in germ-free rats and FITZGERALD and colleagues (FITZGERALD and KEYES 1960; FITZGERALD et al. 1960) found that maximum cariogenicity in germ-free animals was observed following infection with streptococci of the type originally described by CLARKE. It was subsequently demonstrated that S. mutans is the principal etiological agent of dental caries in humans (see NEWBRUN 1978). S. mutans only colonizes humans following tooth eruption during the 1st year of life, with most humans being colonized during early childhood (STILES et al. 1976).
克隆到质粒pBR322中的变形链球菌天冬氨酸半醛脱氢酶基因的表达。
DOI: 10.1099/00221287-128-5-1135
发表时间: 1982
期刊: Journal of general microbiology
影响因子: --
作者:
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DOI: 10.1016/0378-1119(83)90176-2
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影响因子: 3.5
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发表时间: 1982
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影响因子: --
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DOI: 10.1099/00221287-130-10-2497
发表时间: 1984
期刊: Journal of general microbiology
影响因子: --
作者:
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通讯作者: Trapa,V
枯草芽孢杆菌与粪链球菌转座子 Tn917 的遗传转座和插入诱变。
DOI: 10.1073/pnas.80.8.2305
发表时间: 1983
影响因子: 11.1
作者:
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