STAT4 and T-bet control follicular helper T cell development in viral infections.
STAT4 and T-bet control follicular helper T cell development in viral infections.
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DOI：
10.1084/jem.20170457
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发表时间：
2018-01-02
期刊：
影响因子：
--
通讯作者：
Craft J
中科院分区：
文献类型：
--
作者：
Weinstein JS;Laidlaw BJ;Lu Y;Wang JK;Schulz VP;Li N;Herman EI;Kaech SM;Gallagher PG;Craft J
Weinstein et al. demonstrate that the transcription factors T-bet and STAT4 are necessary for Tfh cell expansion with secretion of IFN-γ and IL-21 and consequent robust germinal center output during acute viral infection. Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-γ. IL-21 and IFN-γ are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-γ, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN-γ and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-γ production and for promotion of the GC response after acute viral challenge.
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DOI：
10.1084/jem.20101773
发表时间：
2011-05-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fahey LM;Wilson EB;Elsaesser H;Fistonich CD;McGavern DB;Brooks DG
通讯作者：
Brooks DG
影响因子：
32.4
作者：
Iwata S;Mikami Y;Sun HW;Brooks SR;Jankovic D;Hirahara K;Onodera A;Shih HY;Kawabe T;Jiang K;Nakayama T;Sher A;O'Shea JJ;Davis FP;Kanno Y
通讯作者：
Kanno Y
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
DOI：
10.1084/jem.20111174
发表时间：
2012-02-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Johnston RJ;Choi YS;Diamond JA;Yang JA;Crotty S
通讯作者：
Crotty S
影响因子：
20.3
作者：
Eddahri, Fouad;Denanglaire, Sebastien;Andris, Fabienne
通讯作者：
Andris, Fabienne