Clinicopathological characteristics of non-diabetic renal disease in patients with type 2 diabetes mellitus in a northeastern Chinese medical center: a retrospective analysis of 273 cases.
Clinicopathological characteristics of non-diabetic renal disease in patients with type 2 diabetes mellitus in a northeastern Chinese medical center: a retrospective analysis of 273 cases.
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DOI：
10.1007/s11255-016-1331-y
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发表时间：
2016-10
影响因子：
2
通讯作者：
Sun, Guangdong
中科院分区：
文献类型：
--
作者：
Liu, Shujun;Guo, Qiaoyan;Han, Hongbo;Cui, Peihe;Liu, Xiao;Miao, Lining;Zou, Hongbin;Sun, Guangdong
关键词：
探讨中国东北地区2型糖尿病（T2D）合并糖尿病肾病（DN）的非糖尿病肾病（NDRD）的临床和病理特点，并与单纯DN和单纯NDRD进行比较。基于2000年2月至2015年10月期间接受肾活检的273例T2D患者（172例男性，平均年龄：51.1 ± 12.4岁）的病历的单中心回顾性分析。所有患者均诊断为单纯DN、单纯NDRD或NDRD合并DN。在273例T2D患者中，68例（24.9%）患有DN，175例（64.1%）患有NDRD，30例（11.0%）NDRD叠加DN。原发性膜性肾病（IMN，29.7%）是最常见的NDRD，其次是伊加肾病（IgAN，22.9%），高血压肾小动脉硬化是NDRD合并DN患者最常见的病变。NDRD患者的糖尿病病程较短，糖尿病视网膜病变（DR，6.9%）和肾衰竭（28.0%）的发生率较低，这与较高的估计肾小球滤过率（eGFR）和较低的收缩压（SBP）一致。在蛋白尿和血尿方面未观察到显著的组间差异。建议对T2D患者进行肾活检，以区分DN、NDRD和NDRD叠加DN，尤其是无DR体征的患者。这种方法有助于早期诊断和治疗NDRD，改善中国东北地区T2D患者的肾脏预后。
To investigate the clinical and histopathological features of non-diabetic renal disease (NDRD) superimposed on diabetic nephropathy (DN) in northeastern Chinese patients with type 2 diabetes mellitus (T2D), and compare the changes with those of pure DN and isolated NDRD. Single-center retrospective analysis based on medical records of 273 patients (172 men, mean age: 51.1 ± 12.4 years) with T2D who underwent renal biopsy between February 2000 and October 2015. All patients were diagnosed as cases of pure DN, isolated NDRD or NDRD superimposed on DN. Out of the 273 T2D patients, 68 (24.9 %) had DN, 175 (64.1 %) had NDRD, and 30 (11.0 %) had NDRD superimposed on DN. Idiopathic membranous nephropathy (IMN, 29.7 %) was the most common NDRD followed by IgA nephropathy (IgAN, 22.9 %), and hypertensive renal arteriolar sclerosis was the most common lesion in patients diagnosed as NDRD superimposed on DN. Patients with NDRD had a shorter duration of diabetes and lower frequencies of diabetic retinopathy (DR, 6.9 %) and renal failure (28.0 %), which is consistent with higher estimated glomerular filtration rates (eGFR) and lower systolic blood pressure (SBP). No significant between-group differences were observed with respect to proteinuria and hematuria. Renal biopsy is strongly recommended for T2D patients to distinguish DN, NDRD and NDRD superimposed on DN, especially in patients with no signs of DR. This approach may help in early diagnosis and treatment of NDRD and improve renal outcomes in northeastern Chinese T2D patients.
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影响因子：
3.2
作者：
Dong ZY;Wang YD;Qiu Q;Hou K;Zhang L;Wu J;Zhu HY;Cai GY;Sun XF;Zhang XG;Liu MY;Kou J;Chen XM
通讯作者：
Chen XM
影响因子：
3.7
作者：
Liang S;Zhang XG;Cai GY;Zhu HY;Zhou JH;Wu J;Chen P;Lin SP;Qiu Q;Chen XM
通讯作者：
Chen XM
影响因子：
1.6
作者：
Lu, B.;Gong, W.;Hu, R.
通讯作者：
Hu, R.
影响因子：
5.1
作者：
Tone, A;Shikata, K;Makino, H
通讯作者：
Makino, H
影响因子：
1.6
作者：
Ghani AA;Al Waheeb S;Al Sahow A;Hussain N
通讯作者：
Hussain N