Sex and speciation: the paradox that non-recombining DNA promotes recombination.
Sex and speciation: the paradox that non-recombining DNA promotes recombination.
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DOI：
10.1016/j.fbr.2011.07.003
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发表时间：
2011-10-01
影响因子：
6
通讯作者：
Idnurm, Alexander
中科院分区：
文献类型：
--
作者：
Idnurm, Alexander
有性生殖的好处大于其成本，这一直困扰着生物学家。新的等位基因组合产生的遗传多样性增加，在减数分裂过程中重组增强，被认为是性别的主要好处。性别决定系统已经在许多场合独立进化。其中最熟悉的是脊椎动物性染色体的使用。其他真核生物也使用性染色体或染色体内较小的性别决定区域，例如真菌中的交配型基因座。在这些生物体中，有性生殖及其相关的减数分裂重组是由基因组中自身在重组中被阻断的区域控制的。非重组DNA是重组所必需的，这是一个悖论。一种假设是，性别决定需要或导致高度多样化的等位基因，建立这种重组的障碍。第二个解释这些类型的性别决定系统普遍存在的假设是，它们结合了重组抑制和生殖隔离的联合收割机机制，从而促进了新物种的进化。真菌界代表了理想的真核生物谱系，以阐明性别决定和物种形成中的非重组区域的功能。
The benefits of sexual reproduction that outweigh its costs have long puzzled biologists. Increased genetic diversity generated by new allelic combinations, as enhanced by recombination during meiosis, is considered to be a primary benefit of sex. Sex-determining systems have evolved independently on numerous occasions. One of the most familiar is the use of sex chromosomes in vertebrates. Other eukaryotic groups also use sex chromosomes or smaller sex-determining regions within their chromosomes, such as the mating type loci in the fungi. In these organisms, sexual reproduction and its associated meiotic recombination is controlled by regions of the genome that are themselves blocked in recombination. Non-recombining DNA that is essential for recombination presents a paradox. One hypothesis is that sex-determination requires or leads to highly diverse alleles, establishing this block in recombination. A second hypothesis to account for the common occurrence of these types of sex-determining systems is that they combine mechanisms for recombination suppression and reproductive isolation, thereby promoting the evolution of new species. The fungal kingdom represents the ideal eukaryotic lineage to elucidate the functions of non-recombining regions in sex-determination and speciation.
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DOI：
10.1073/pnas.0304170101
发表时间：
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影响因子：
11.1
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影响因子：
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影响因子：
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