Autophagic cell death and cancer.

Autophagic cell death and cancer.
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DOI:
10.3390/ijms15023145
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发表时间:
2014-02-21
影响因子:
5.6
通讯作者:
Arakawa S
Arakawa S
中科院分区:
生物学2区
文献类型:
--
作者:
Shimizu S;Yoshida T;Tsujioka M;Arakawa S

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细胞程序性死亡(PCD)是后生动物正常发育和生理所必需的重要过程。诱导PCD的三种主要机制被称为I型(凋亡)、II型(自噬性细胞死亡)和III型(坏死性细胞死亡)。功能失调的PCD导致疾病,如癌症和神经变性。虽然细胞凋亡是PCD最常见的形式,但最近的研究提供了证据,表明还有其他形式的细胞死亡。这种细胞死亡之一是自噬性细胞死亡,其通过自噬的激活而发生。本文就自噬性细胞死亡及其与肿瘤发生的关系作一综述。
Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.
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