A comparative review of evaporative dry eye disease and meibomian gland dysfunction in dogs and humans.
A comparative review of evaporative dry eye disease and meibomian gland dysfunction in dogs and humans.
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DOI：
10.1111/vop.13066
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发表时间：
2023-04
影响因子：
1.6
通讯作者：
Leonard, Brian C.
中科院分区：
文献类型：
--
作者：
Hisey, Erin A.;Galor, Anat;Leonard, Brian C.
关键词：
干眼病是一种复杂的眼科疾病，由两种主要亚型组成，即水缺乏性干眼病（ADDE）和蒸发性干眼病（EDED）。由于复杂的潜在生理学，人类干眼病可能难以在实验室动物物种中建模。因此，干眼病的自发性大型动物模型的鉴定和表征是期望的。由于犬与人的病理生理学相似，犬被描述为ADDE的理想自发模型。近年来，EDED和睑板腺功能障碍（MGD）已越来越多地被认识和报道。这些关于犬中EDED和MGD的报告已确定了与患有类似疾病的人类在病理生理学、临床表现和诊断参数方面的相似性。此外，由于犬和人之间的地球仪大小相当，用于诊断人体EDED和MGD的试验更容易适用于犬而不是实验室种属。狗对EDED和MGD治疗的反应与人类相似，表明它们将是开发其他治疗方法的有价值的临床前模型。对犬中EDED和MGD的进一步研究和临床认识将提高其用作临床前模型的能力，提高人和犬中EDED和MGD治疗剂的阳性预测值。
Dry eye disease is a complex ophthalmic disorder that consists of two main subtypes, aqueous deficient dry eye (ADDE) and evaporative dry eye disease (EDED). Due to the complex underlying physiology, human dry eye disease can be difficult to model in laboratory animal species. Thus, the identification and characterization of a spontaneous large animal model of dry eye disease is desirable. Dogs have been described as an ideal spontaneous model of ADDE due to the similar pathophysiology between dogs and humans. Recently, EDED and meibomian gland dysfunction (MGD) have been increasingly recognized and reported in dogs. These reports on EDED and MGD in dogs have identified similarities in pathophysiology, clinical presentations, and diagnostic parameters to humans with the comparable disorders. Additionally, the tests that are used to diagnose EDED and MGD in humans are more easily applicable to dogs than to laboratory species due to the comparable globe sizes between dogs and humans. The reported response of dogs to EDED and MGD therapies are similar to humans, suggesting that they would be a valuable preclinical model for the development of additional therapeutics. Further research and clinical awareness of EDED and MGD in dogs would increase their ability to be utilized as a preclinical model, improving the positive predictive value of therapeutics for EDED and MGD in both humans and dogs.
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影响因子：
2.8
作者：
Arita, Reiko;Itoh, Kouzo;Amano, Shiro
通讯作者：
Amano, Shiro
影响因子：
2.9
作者：
Costa J;Steinmetz A;Delgado E
通讯作者：
Delgado E
影响因子：
1.6
作者：
Brito, Fabio L. da C.;Voitena, Jessica N.;Montiani-Ferreira, Fabiano
通讯作者：
Montiani-Ferreira, Fabiano
DOI：
10.1016/s0195-5616(94)50080-9
发表时间：
1994-07-01
影响因子：
1.9
作者：
BISTNER, S
通讯作者：
BISTNER, S
DOI：
10.1097/icl.0000000000000729
发表时间：
2021-01-01
期刊：
Eye & contact lens
影响因子：
--
作者：
Arita R;Fukuoka S
通讯作者：
Fukuoka S