Lithium Ion Nanocarriers Self-Assembled from Amphiphiles with Aggregation-Induced Emission Activity
Lithium Ion Nanocarriers Self-Assembled from Amphiphiles with Aggregation-Induced Emission Activity
复制标题
具有聚集诱导发射活性的两亲物自组装锂离子纳米载体
DOI：
10.1021/acsanm.7b00050
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Yun Yan
中科院分区：
文献类型：
--
作者：
Rongrong Xue;Yuchun Han;Yunlong Xiao;Jianbin Huang;Ben Zhong Tang;Yun Yan
锂盐被广泛用于治疗躁郁症或慢性还原等疾病，但由于锂离子在周围器官中积累，它们经常会引发患者的不良副作用。传统的制备纳米载体的方法不适用于锂离子，因为锂离子很难与水中的分子牢固结合，并且由于其小尺寸和高水溶性而容易泄漏。我们报道了在水中成功地制备锂离子纳米载体，其中两亲分子包含两个环氧乙烷四聚体，连接在疏水核心上，显示出聚集诱导的光发射(AIE)。两亲分子在水中自组装成荧光球形聚集体。锂离子通过与环氧乙烷四聚体结合而负载到球形聚集体中。这种纳米载体可以通过内吞过程很容易地进入细胞，在高达100μM的浓度下不影响细胞活力。
Lithium salts are extensively used to treat diseases such as bipolar disorder or chronic reduction, but they often trigger undesirable side effects in patients due to the accumulation of lithium ions in peripheral organs. A conventional strategy for fabricating nanocarriers is not applicable to lithium ions because of their difficulty in binding firmly to molecules in water and easy leakage due to their small size and high water solubility. We report here the successful fabrication of lithium ion nanocarriers in water with an amphiphile containing two ethylene oxide tetramers attached to a hydrophobic core showing aggregation-induced light emission (AIE). The amphiphile self-assembles into fluorescent spherical aggregates in water. Lithium ions are loaded into the spherical aggregates by binding to the ethylene oxide tetramer. This nanocarrier can enter cells facilely via an endocytosis process and does not affect the cell viability at concentrations of up to 100 μM. Moreover, the self-imaging ability of ...
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影响因子：
4.1
作者：
Croce, Nicoletta;Mathe, Aleksander A.;Angelucci, Francesco
通讯作者：
Angelucci, Francesco
影响因子：
3.8
作者：
Duggirala, Naga Kiran;Smith, Adam J.;Zaworotko, Michael J.
通讯作者：
Zaworotko, Michael J.
DOI：
10.1055/s-0033-1345098
发表时间：
2013-11
期刊：
Journal of Neurological Surgery—Part A
影响因子：
--
作者：
Marjan Zakeri;Khashayar Afshari;M. Gharedaghi;R. Shahsiah;R. Rahimian;F. Maleki;A. Dehpour;A. Javidan
通讯作者：
Marjan Zakeri;Khashayar Afshari;M. Gharedaghi;R. Shahsiah;R. Rahimian;F. Maleki;A. Dehpour;A. Javidan
影响因子：
3.4
作者：
Limin Xu;Liangzhu Feng;Yuchun Han;Yu Jing;Zhaoyang Xian;Zhuang Liu;Jianbin Huang;Yun Yan
通讯作者：
Limin Xu;Liangzhu Feng;Yuchun Han;Yu Jing;Zhaoyang Xian;Zhuang Liu;Jianbin Huang;Yun Yan
影响因子：
4.3
作者：
ThiesFlechtner, K;MullerOerlinghausen, B;Greil, W
通讯作者：
Greil, W