Reliability and Reproducibility of Neuromelanin-Sensitive Imaging of the Substantia Nigra: A Comparison of Three Different Sequences.
Reliability and Reproducibility of Neuromelanin-Sensitive Imaging of the Substantia Nigra: A Comparison of Three Different Sequences.
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DOI：
10.1002/jmri.27384
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
van de Giessen E
中科院分区：
文献类型：
--
作者：
van der Pluijm M;Cassidy C;Zandstra M;Wallert E;de Bruin K;Booij J;de Haan L;Horga G;van de Giessen E
黑质神经黑色素敏感 MRI (NM-MRI) 提供了一种非侵入性方法来间接测量多巴胺功能。尽管 NM-MRI 有潜力作为多巴胺能病理学的候选生物标志物，但有关其重复性的研究却很少。评估三种常用 NM-MRI 序列的重测重现性并评估三种分析方法。前瞻性研究。共有 11 名健康参与者，年龄在 20 至 27 岁之间。 3.0吨； NM-MRI 梯度回忆回波 (GRE) 和磁化转移 (MT) 脉冲； NM-MRI 涡轮自旋回波 (TSE) 与 MT 脉冲；无 MT 脉冲的 NM-MRI TSE。参与者被扫描两次，间隔三周。对体积和对比度 (CR) 测量进行手动分析、阈值分析和体素分析。计算重测以及评估者间和评估者内变异性的组内相关系数（ICC）。 GRE 序列实现了最高的对比度和最低的变异性 (4.9–5.7%)，并且在 CR 测量中显示出基本到几乎完美的重测 ICC (0.72–0.90)。对于体积测量，与其他分析方法相比，手动分析显示出更高的变异性 (10.7–17.9%)，并且重测 ICC 得分较低 (–0.13–0.73)。阈值分析显示比体积测量的手动分析更高的重测 ICC (0.77)。 NM-MRI 是一种高度可重复的测量方法，特别是在使用 GRE 序列和 CR 测量时。体积测量似乎对评估者之间/内部的变异性以及 NM-MRI 板的放置和方向的变异性更加敏感。阈值分析似乎是体积分析的最佳替代方案。 2 1
Neuromelanin‐sensitive MRI (NM‐MRI) of the substantia nigra provides a noninvasive way to acquire an indirect measure of dopamine functioning. Despite the potential of NM‐MRI as a candidate biomarker for dopaminergic pathology, studies about its reproducibility are sparse. To assess the test–retest reproducibility of three commonly used NM‐MRI sequences and evaluate three analysis methods. Prospective study. A total of 11 healthy participants age between 20–27 years. 3.0T; NM‐MRI gradient recalled echo (GRE) with magnetization transfer (MT) pulse; NM‐MRI turbo spin echo (TSE) with MT pulse; NM‐MRI TSE without MT pulse. Participants were scanned twice with a 3‐week interval. Manual analysis, threshold analysis, and voxelwise analysis were performed for volume and contrast ratio (CR) measurements. Intraclass correlation coefficients (ICCs) were calculated for test–retest and inter‐ and intrarater variability. The GRE sequence achieved the highest contrast and lowest variability (4.9–5.7%) and showed substantial to almost perfect test–retest ICC (0.72–0.90) for CR measurements. For volume measurements, the manual analysis showed a higher variability (10.7–17.9%) and scored lower test–retest ICCs (–0.13–0.73) than the other analysis methods. The threshold analysis showed higher test–retest ICC (0.77) than the manual analysis for the volume measurements. NM‐MRI is a highly reproducible measure, especially when using the GRE sequence and CR measurements. Volume measurements appear to be more sensitive to inter/intrarater variability and variability in placement and orientation of the NM‐MRI slab. The threshold analysis appears to be the best alternative for volume analysis. 2 1
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影响因子：
10.6
作者：
Shibata, Eri;Sasaki, Makoto;Sakai, Akio
通讯作者：
Sakai, Akio
影响因子：
2.5
作者：
Ohtsuka, Chigumi;Sasaki, Makoto;Terayama, Yasuo
通讯作者：
Terayama, Yasuo
影响因子：
5.7
作者：
Liu, Yu;Li, Junchen;Haacke, E. Mark
通讯作者：
Haacke, E. Mark
影响因子：
8.6
作者：
Schwarz, Stefan T.;Rittman, Timothy;Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
影响因子：
3.5
作者：
Pyatigorskaya, N.;Magnin, B.;Lehericy, S.
通讯作者：
Lehericy, S.