Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.
Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.
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DOI：
10.1186/1471-2350-11-17
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发表时间：
2010-01-30
影响因子：
--
通讯作者：
Lin MC
中科院分区：
文献类型：
--
作者：
Chen YC;Hsiao CC;Chen CJ;Chin CH;Liu SF;Wu CC;Eng HL;Chao TY;Tsen CC;Wang YH;Lin MC
探讨Toll样受体2基因多态性对肺结核易感性、肺结核表型及血淋巴细胞亚群的影响。共检测了368名受试者（包括184名肺结核患者和184名健康对照）在微卫星鸟嘌呤-胸腺嘧啶重复序列（-100）、-16934（T>A）、-15607（A>G）、-196至-174（插入>缺失）和1350（T>C）位点上的TLR 2多态性。对86例肺结核患者进行了外周血淋巴细胞亚群检测。我们新发现单倍型[A-G-（插入）-T]与肺结核易感性之间存在关联（p = 0.006，错误发现率q = 0.072）。有全身症状的TB患者的-196至-174缺失/缺失基因型频率低于无全身症状的患者（5.7% vs. 17.7%; p = 0.01）。携带缺失/缺失基因型的TB患者的血液NK细胞计数高于携带插入等位基因的患者（526 vs. 243.5 cells/μl，p = 0.009）。有胸膜炎的结核病患者的1350 CC基因型频率高于无胸膜炎的患者（12.5%对2.1%; p = 0.004）。携带1350 CC基因型的TB患者的血液NK细胞计数高于携带T等位基因的患者（641 vs. 250 cells/μl，p = 0.004）。携带GT重复纯合短等位基因的TB患者的血液NK细胞计数高于携带一个或不携带短等位基因的患者（641 vs. 250 cells/μl，p = 0.004）。TLR 2基因多态性影响肺结核易感性TLR 2变体在TB表型的发展中起作用，可能通过控制NK细胞的扩增。
To investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB, its phenotypes, and blood lymphocyte subsets. A total of 368 subjects, including 184 patients with pulmonary TB and 184 healthy controls, were examined for TLR2 polymorphisms over locus -100 (microsatellite guanine-thymine repeats), -16934 (T>A), -15607 (A>G), -196 to -174 (insertion>deletion), and 1350 (T>C). Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations. We newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = 0.006, false discovery rate q = 0.072). TB patients with systemic symptoms had a lower -196 to -174 deletion/deletion genotype frequency than those without systemic symptoms (5.7% vs. 17.7%; p = 0.01). TB patients with the deletion/deletion genotype had higher blood NK cell counts than those carrying the insertion allele (526 vs. 243.5 cells/μl, p = 0.009). TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis (12.5% vs. 2.1%; p = 0.004). TB patients with the 1350 CC genotype had higher blood NK cell counts than those carrying the T allele (641 vs. 250 cells/μl, p = 0.004). TB patients carrying homozygous short alleles for GT repeats had higher blood NK cell counts than those carrying one or no short allele (641 vs. 250 cells/μl, p = 0.004). TLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB phenotypes, probably by controlling the expansion of NK cells.
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