Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis.
Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis.
复制标题
DOI：
10.3390/toxics11121014
复制
发表时间：
2023-12-12
期刊：
影响因子：
4.6
通讯作者：
Corlin L
中科院分区：
文献类型：
--
作者：
Casella C;Kiles F;Urquhart C;Michaud DS;Kirwa K;Corlin L
越来越多的文献试图描述交通相关空气污染（TRAP）如何影响分子和亚临床生物过程，从而导致心肺疾病。为了提供一个精简的综合什么是已知的多种机制，通过TRAP可能会导致心肺病理，我们进行了系统的流行病学文献综述，有关TRAP暴露于甲基化，蛋白质组学和代谢组学生物标志物在成年人群。使用符合我们纳入标准的139篇论文，我们确定了与短期或长期TRAP显著相关的组学生物标志物，并使用这些生物标志物进行通路和网络分析。我们考虑了TRAP与生物学途径相关的证据，这些生物学途径包括脂质代谢、细胞能量产生、氨基酸代谢、炎症和免疫、凝血、内皮功能和氧化应激。我们的分析表明，一个综合的多组学方法可能会提供关键的新见解的方式TRAP可能会导致不良的临床结果。我们主张努力建立一个更加统一的方法来表征TRAP暴露与亚临床和临床疾病之间的动态和复杂的生物过程，并强调与这些努力相关的当代挑战和机遇。
A growing body of literature has attempted to characterize how traffic-related air pollution (TRAP) affects molecular and subclinical biological processes in ways that could lead to cardiorespiratory disease. To provide a streamlined synthesis of what is known about the multiple mechanisms through which TRAP could lead to cardiorespiratory pathology, we conducted a systematic review of the epidemiological literature relating TRAP exposure to methylomic, proteomic, and metabolomic biomarkers in adult populations. Using the 139 papers that met our inclusion criteria, we identified the omic biomarkers significantly associated with short- or long-term TRAP and used these biomarkers to conduct pathway and network analyses. We considered the evidence for TRAP-related associations with biological pathways involving lipid metabolism, cellular energy production, amino acid metabolism, inflammation and immunity, coagulation, endothelial function, and oxidative stress. Our analysis suggests that an integrated multi-omics approach may provide critical new insights into the ways TRAP could lead to adverse clinical outcomes. We advocate for efforts to build a more unified approach for characterizing the dynamic and complex biological processes linking TRAP exposure and subclinical and clinical disease and highlight contemporary challenges and opportunities associated with such efforts.
登录
查看更多内容
影响因子：
4.6
作者：
van Paridon, Pauline C. S.;Panova-Noeva, Marina;van Oerle, Rene;Schulz, Andreas;Prochaska, Juergen H.;Arnold, Natalie;Schmidtmann, Irene;Beutel, Manfred;Pfeiffer, Norbert;Muenzel, Thomas;Lackner, Karl J.;ten Cate, Hugo;Wild, Philipp S.;Spronk, Henri M. H.
通讯作者：
Spronk, Henri M. H.
DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
10.4
作者：
Alexeeff SE;Coull BA;Gryparis A;Suh H;Sparrow D;Vokonas PS;Schwartz J
通讯作者：
Schwartz J
影响因子：
10.4
作者：
Bind MA;Peters A;Koutrakis P;Coull B;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
4.6
作者：
Pradhan SN;Das A;Meena R;Nanda RK;Rajamani P
通讯作者：
Rajamani P