Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function.
Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function.
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DOI：
10.1289/ehp.1002560
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发表时间：
2011-04
影响因子：
10.4
通讯作者：
Schwartz J
中科院分区：
文献类型：
--
作者：
Alexeeff SE;Coull BA;Gryparis A;Suh H;Sparrow D;Vokonas PS;Schwartz J
暴露于与交通相关的空气污染(TRAP)会增加心血管风险。土地利用回归模型可以改善圈闭的暴露评估。我们研究了通过土地利用回归估计的黑碳(BC)中期浓度与炎症和内皮反应的标志物--可溶性细胞间黏附分子-1(sICAM-1)和可溶性血管细胞黏附分子-1(sVCAM-1)水平之间的关系。我们研究了参加退伍军人管理局(VA)标准老龄化研究的642名老年男性，在1999-2008年间重复测量sICAM-1和sVCAM-1。使用经过验证的时空模型得出每个地理编码参与者地址的每日BC暴露估计值，并将其平均形成4周、8周和12周的暴露。我们使用线性混合模型来估计相关性，控制混杂因素。我们检查了他汀类药物的使用、肥胖和糖尿病对疗效的影响。我们发现，在4、8和12周的平均时间内，BC和sICAM-1之间存在统计学上显著的正相关。8周BC暴露(0.30μg/m~3)四分位数范围内增加与sICAM-1增加1.58%(95%可信区间，0.18-3.00%)相关。总体而言，sVCAM-1和BC暴露之间的关联具有提示性，但在统计学上没有显著意义。我们发现sICAM-1和sVCAM-1与糖尿病有显著的相互作用，糖尿病患者更容易受到BC的影响。我们还观察到了与他汀类药物使用的相互作用，这对sVCAM-1具有统计学意义，并提示sICAM-1。我们没有发现与肥胖症相互作用的证据。我们的结果表明，中期暴露于TRAP可能会导致炎症/内皮反应增加，特别是在糖尿病患者和未使用他汀类药物的患者中。
Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regression and levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), both markers of inflammatory and endothelial response. We studied 642 elderly men participating in the Veterans Administration (VA) Normative Aging Study with repeated measurements of sICAM-1 and sVCAM-1 during 1999–2008. Daily estimates of BC exposure at each geocoded participant address were derived using a validated spatiotemporal model and averaged to form 4-, 8-, and 12-week exposures. We used linear mixed models to estimate associations, controlling for confounders. We examined effect modification by statin use, obesity, and diabetes. We found statistically significant positive associations between BC and sICAM-1 for averages of 4, 8, and 12 weeks. An interquartile-range increase in 8-week BC exposure (0.30 μg/m3) was associated with a 1.58% increase in sICAM-1 (95% confidence interval, 0.18–3.00%). Overall associations between sVCAM-1 and BC exposures were suggestive but not statistically significant. We found a significant interaction with diabetes—where diabetics were more susceptible to the effect of BC—for both sICAM-1 and sVCAM-1. We also observed an interaction with statin use, which was statistically significant for sVCAM-1 and suggestive for sICAM-1. We found no evidence of an interaction with obesity. Our results suggest that medium-term exposure to TRAP may induce an increased inflammatory/endothelial response, especially among diabetics and those not using statins.
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影响因子：
5.4
作者：
Brauer, M;Hoek, G;Brunekreef, B
通讯作者：
Brunekreef, B
影响因子：
37.8
作者：
O'Neill, MS;Veves, A;Schwartz, J
通讯作者：
Schwartz, J
影响因子：
16.2
作者：
Lim, SC;Caballero, AE;Veves, A
通讯作者：
Veves, A
影响因子：
5.4
作者：
Forastiere, Francesco;Stafoggia, Massimo;Perucci, Carlo A.
通讯作者：
Perucci, Carlo A.
与短期接触交通颗粒和硫酸盐相关的死亡风险。
影响因子：
10.4
作者：
Maynard D;Coull BA;Gryparis A;Schwartz J
通讯作者：
Schwartz J