Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature.
Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature.
复制标题
复发性和进展性脑膜瘤的潜在分子机制：最新文献综述
DOI：
10.3389/fonc.2022.850463
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
脑膜瘤是成人中枢神经系统最常见的原发性颅内肿瘤，起源于脑膜和脑膜间隙。手术切除和辅助放疗被认为是首选的治疗方案。虽然大多数脑膜瘤是良性的，生长缓慢，但有些患者会出现肿瘤复发和疾病进展，最终导致临床结局较差，包括恶变和死亡。因此，早期识别这些“高危”肿瘤至关重要;这需要深入了解分子和遗传改变，从而为未来建立个性化和精确治疗提供理论基础。在这里，我们回顾了最新的知识脑膜瘤的进展，包括细胞增殖，新生血管生成，细胞凋亡的抑制和免疫原性的细胞生物学改变。重点遗传改变，包括染色体异常和DNA甲基化模式，进行了总结和详细讨论。我们还介绍了脑膜瘤治疗的最新靶点和临床试验。对细胞生物学和遗传学改变的进一步了解将为复发性和进展性脑膜瘤的准确筛查和治疗提供新的前景。
Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. It is thus crucial to identify these “high-risk” tumors early; this requires an in-depth understanding of the molecular and genetic alterations, thereby providing a theoretical foundation for establishing personalized and precise treatment in the future. Here, we review the most up-to-date knowledge of the cellular biological alterations involved in the progression of meningiomas, including cell proliferation, neo-angiogenesis, inhibition of apoptosis, and immunogenicity. Focused genetic alterations, including chromosomal abnormalities and DNA methylation patterns, are summarized and discussed in detail. We also present latest therapeutic targets and clinical trials for meningiomas' treatment. A further understanding of cellular biological and genetic alterations will provide new prospects for the accurate screening and treatment of recurrent and progressive meningiomas.
登录
查看更多内容
DOI：
10.1038/s41436-020-0792-7
发表时间：
2020-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Castilla-Vallmanya L;Selmer KK;Dimartino C;Rabionet R;Blanco-Sánchez B;Yang S;Reijnders MRF;van Essen AJ;Oufadem M;Vigeland MD;Stadheim B;Houge G;Cox H;Kingston H;Clayton-Smith J;Innis JW;Iascone M;Cereda A;Gabbiadini S;Chung WK;Sanders V;Charrow J;Bryant E;Millichap J;Vitobello A;Thauvin C;Mau-Them FT;Faivre L;Lesca G;Labalme A;Rougeot C;Chatron N;Sanlaville D;Christensen KM;Kirby A;Lewandowski R;Gannaway R;Aly M;Lehman A;Clarke L;Graul-Neumann L;Zweier C;Lessel D;Lozic B;Aukrust I;Peretz R;Stratton R;Smol T;Dieux-Coëslier A;Meira J;Wohler E;Sobreira N;Beaver EM;Heeley J;Briere LC;High FA;Sweetser DA;Walker MA;Keegan CE;Jayakar P;Shinawi M;Kerstjens-Frederikse WS;Earl DL;Siu VM;Reesor E;Yao T;Hegele RA;Vaske OM;Rego S;Undiagnosed Diseases Network, Care4Rare Canada Consortium;Shapiro KA;Wong B;Gambello MJ;McDonald M;Karlowicz D;Colombo R;Serretti A;Pais L;O'Donnell-Luria A;Wray A;Sadedin S;Chong B;Tan TY;Christodoulou J;White SM;Slavotinek A;Barbouth D;Morel Swols D;Parisot M;Bole-Feysot C;Nitschké P;Pingault V;Munnich A;Cho MT;Cormier-Daire V;Balcells S;Lyonnet S;Grinberg D;Amiel J;Urreizti R;Gordon CT
通讯作者：
Gordon CT
DOI：
10.26355/eurrev_201908_18556
发表时间：
2019-08-01
影响因子：
3.3
作者：
Che, Q-Q;Huang, T.;Qian, X-J
通讯作者：
Qian, X-J
影响因子：
4.7
作者：
Deng J;Sun S;Chen J;Wang D;Cheng H;Chen H;Xie Q;Hua L;Gong Y
通讯作者：
Gong Y
影响因子：
15.9
作者：
Abedalthagafi, Malak;Bi, Wenya Linda;Santagata, Sandro
通讯作者：
Santagata, Sandro
影响因子：
13.6
作者：
Bayley, James C.;Hadley, Caroline C.;Patel, Akash J.
通讯作者：
Patel, Akash J.