C/EBPδ drives key endocrine signals in the human amnion at parturition.
C/EBPδ drives key endocrine signals in the human amnion at parturition.
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DOI：
10.1002/ctm2.416
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发表时间：
2021-06
影响因子：
10.6
通讯作者：
Sun K
中科院分区：
文献类型：
--
作者：
Lu JW;Wang WS;Zhou Q;Ling LJ;Ying H;Sun Y;Myatt L;Sun K
羊膜来源的前列腺素E2（PGE 2）和皮质醇是分娩开始的关键。鉴定一种共同的转录因子，驱动环氧合酶-2（考克斯-2）和11β-羟基类固醇脱氢酶1（11β-HSD 1）（其产生的关键酶）的表达，可能是治疗早产的关键。在这里，我们发现CCAAT增强子结合蛋白δ（C/EBPδ）是这样一种转录因子，它是人羊膜成纤维细胞中考克斯-2和11β-HSD 1自身产物PGE 2和皮质醇前馈诱导表达的基础，从而确保它们在羊膜中的产生以用于分娩的开始。此外，羊膜中C/EBPδ的丰度在足月时随着考克斯-2和11β-HSD 1的增加而沿着增加，并在分娩时进一步增加。敲除小鼠中的C/EBPδ延迟分娩的开始，进一步支持该概念。总之，C/EBPδ通路可能被推测为羊膜中治疗早产的潜在药物靶点。C/EBPδ在羊膜中的表达随孕周和分娩而增加。C/EBPδ能够诱导羊膜中皮质醇再生和前列腺素产生，这是分娩启动中的关键内分泌事件。C/EBPδ通路的抑制可能会延迟早产分娩的开始。
Amnion‐derived prostaglandin E2 (PGE2) and cortisol are key to labor onset. Identification of a common transcription factor driving the expression of both cyclooxygenase‐2 (COX‐2) and 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1), the key enzymes in their production, may hold the key to the treatment of pre‐term labor. Here, we have found that the CCAAT enhancer binding protein δ (C/EBPδ) is such a transcription factor which underlies the feed‐forward induction of COX‐2 and 11β‐HSD1 expression by their own products PGE2 and cortisol in human amnion fibroblasts so that their production would be ensured in the amnion for the onset of labor. Moreover, the abundance of C/EBPδ in the amnion increases along with COX‐2 and 11β‐HSD1 at term and further increases at parturition. Knockout of C/EBPδ in mice delays the onset of labor further supporting the concept. In conclusion, C/EBPδ pathway may be speculated to serve as a potential pharmaceutical target in the amnion for treatment of pre‐term labor. The expression of C/EBPδ increases with gestation age and in parturition in the amnion of the fetal membranes. C/EBPδ is capable of inducing cortisol regeneration and prostaglandin production, the key endocrine events in parturition initiation, in the amnion. Inhibition of the C/EBPδ pathway may delay labor onset in preterm birth.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
48
作者：
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通讯作者：
Salzberg, Steven L.
影响因子：
5.3
作者：
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通讯作者：
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影响因子：
4.1
作者：
Economopoulos, P;Sun, M;Gibb, W
通讯作者：
Gibb, W
DOI：
10.1016/s0925-4439(00)00016-8
发表时间：
2000-06-15
影响因子：
6.2
作者：
Granger, RL;Hughes, TR;Ramji, DP
通讯作者：
Ramji, DP