Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.
Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.
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DOI：
10.1016/j.cbi.2014.12.022
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发表时间：
2015-06-05
影响因子：
5.1
通讯作者：
Krupenko, Sergey A.
中科院分区：
文献类型：
--
作者：
Krupenko, Natalia I.;Holmes, Roger S.;Tsybovsky, Yaroslav;Krupenko, Sergey A.
胞质和线粒体10-甲酰四氢叶酸脱氢酶是脊椎动物中不同基因的产物，但无脊椎动物中只有一个这样的基因。由于线粒体酶（ALDH 1 L2）的基因明显起源于胞质酶（ALDH 1 L1）基因的复制，因此两种酶之间存在显著程度的序列相似性。原始ALDH 1 L基因起源于三个不相关基因的自然融合，其中一个是醛脱氢酶。这种结构组织定义了这些酶的催化机制，这与醛脱氢酶的催化机制相似。本文报道了ALDH 1 L1和ALDH 1 L2基因在不同物种中的同源性分析及其进化。我们还进行了序列和结构的ALDH 1 L酶具有醛脱氢酶催化那些缺乏这种功能的比较，试图解释细胞质ALDH 1 L1和线粒体ALDH 1 L2酶之间的机制差异，并更好地了解他们的功能作用。
Cytosolic and mitochondrial 10-formyltetrahydrofolate dehydrogenases are products of separate genes in vertebrates but only one such gene is present in invertebrates. There is a significant degree of sequence similarity between the two enzymes due to an apparent origin of the gene for the mitochondrial enzyme (ALDH1L2) from the duplication of the gene for the cytosolic enzyme (ALDH1L1). The primordial ALDH1L gene originated from a natural fusion of three unrelated genes, one of which was an aldehyde dehydrogenase. Such structural organization defined the catalytic mechanism of these enzymes, which is similar to that of aldehyde dehydrogenases. Here we report the analysis of ALDH1L1 and ALDH1L2 genes from different species and their phylogeny and evolution. We also performed sequence and structure comparison of ALDH1L enzymes possessing aldehyde dehydrogenase catalysis to those lacking this feature in an attempt to explain mechanistic differences between cytoplasmic ALDH1L1 and mitochondrial ALDH1L2 enzymes and to better understand their functional roles.
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影响因子：
2.9
作者：
GARCIAMARTINEZ, LF;APPLING, DR
通讯作者：
APPLING, DR
影响因子：
5.1
作者：
Krupenko, Sergey A.
通讯作者：
Krupenko, Sergey A.
影响因子：
1.6
作者：
Chang, Wen-Ni;Lin, Hung-Chang;Fu, Tzu-Fun
通讯作者：
Fu, Tzu-Fun
影响因子：
14.9
作者：
Dereeper A;Guignon V;Blanc G;Audic S;Buffet S;Chevenet F;Dufayard JF;Guindon S;Lefort V;Lescot M;Claverie JM;Gascuel O
通讯作者：
Gascuel O
影响因子：
5.8
作者：
Oleinik, Natalia V.;Krupenko, Natalia I.;Krupenko, Sergey A.
通讯作者：
Krupenko, Sergey A.