Exploring the cortical evidence of a sensory-discrimination process.

Exploring the cortical evidence of a sensory-discrimination process.
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探索感觉辨别过程的皮质证据。

DOI:
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发表时间:
2002
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
E. Salinas
E. Salinas
中科院分区:
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文献类型:
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作者:
R. Romo;Adrián Hernández;A. Zainos;C. Brody;E. Salinas

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人类和猴子具有相似的能力,可以区分施加在指尖上的两个连续机械振动的频率差异。这个任务可以被理解为一个神经操作链:对两个连续的刺激进行编码,在工作记忆中保持第一个刺激,将第二个刺激与第一个刺激留下的记忆痕迹进行比较,并将比较结果传达给运动装置。当猴子执行任务时,我们通过记录和操纵大脑皮层不同区域的神经元来研究这一神经操作链。结果表明,初级体感皮层(S1)的神经元产生振动触觉刺激的神经表征,与心理物理表现密切相关。基于注入S1神经元簇的微刺激模式的识别与自然刺激产生的识别难以区分。第二体感皮层(S2)、前额叶皮层和内侧运动前皮层(MPC)的神经元在工作记忆部分的不同时间显示第一刺激的痕迹。来自S2和MPC的神经元似乎显示了两种刺激之间的比较,并与行为决定相关。这些神经操作可能有助于这里研究的感觉辨别过程。
Humans and monkeys have similar abilities to discriminate the difference in frequency between two consecutive mechanical vibrations applied to their fingertips. This task can be conceived as a chain of neural operations: encoding the two consecutive stimuli, maintaining the first stimulus in working memory, comparing the second stimulus with the memory trace left by the first stimulus and communicating the result of the comparison to the motor apparatus. We studied this chain of neural operations by recording and manipulating neurons from different areas of the cerebral cortex while monkeys performed the task. The results indicate that neurons of the primary somatosensory cortex (S1) generate a neural representation of vibrotactile stimuli which correlates closely with psychophysical performance. Discrimination based on microstimulation patterns injected into clusters of S1 neurons is indistinguishable from that produced by natural stimuli. Neurons from the secondary somatosensory cortex (S2), prefrontal cortex and medial premotor cortex (MPC) display at different times the trace of the first stimulus during the working-memory component of the task. Neurons from S2 and MPC appear to show the comparison between the two stimuli and correlate with the behavioural decisions. These neural operations may contribute to the sensory-discrimination process studied here.
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