TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.
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DOI:
10.1177/0022034510381264
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发表时间:
2011-04
影响因子:
7.6
通讯作者:
Martin M
Martin M
中科院分区:
医学1区
文献类型:
--
作者:
Brown J;Wang H;Hajishengallis GN;Martin M

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Toll样受体通过检测入侵的病原体在先天免疫中发挥关键作用。TLR参与不同细胞内信号传导分子和与其他调节途径的串扰的能力是形成炎症反应的类型、幅度和持续时间的重要因素。本综述将涵盖TLR所利用的基本信号通路以及这些通路如何调节对病原体的先天免疫反应。
Toll-like receptors play a critical role in innate immunity by detecting invading pathogens. The ability of TLRs to engage different intracellular signaling molecules and cross talk with other regulatory pathways are important factors in shaping the type, magnitude, and duration of the inflammatory response. The present review will cover the fundamental signaling pathways utilized by TLRs and how these pathways regulate the innate immune response to pathogens.
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