TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.
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DOI:
10.1177/0022034510381264
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发表时间:
2011-04
影响因子:
7.6
通讯作者:
Martin M
中科院分区:
文献类型:
--
作者:
Brown J;Wang H;Hajishengallis GN;Martin M
Toll-like receptors play a critical role in innate immunity by detecting invading pathogens. The ability of TLRs to engage different intracellular signaling molecules and cross talk with other regulatory pathways are important factors in shaping the type, magnitude, and duration of the inflammatory response. The present review will cover the fundamental signaling pathways utilized by TLRs and how these pathways regulate the innate immune response to pathogens.
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DOI:
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发表时间:
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影响因子:
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发表时间:
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