99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia
99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia
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99mTc-HYNIC-TOC 用于评估复发性肿瘤诱发的骨软化症
DOI：
10.1097/rlu.0000000000002458
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发表时间：
2019-03
影响因子：
10.6
通讯作者：
景红丽
中科院分区：
文献类型：
--
作者：
景红丽
目的肿瘤性骨软化症（TIO）是一种罕见的副肿瘤性疾病，通常由小的良性肿瘤引起。生长抑素受体显像已成为临床诊断为TIO的新患者中病因肿瘤定位的首选成像。使用生长抑素受体显像对肿瘤进行准确定位，然后成功手术切除，可治愈该病。然而，在一小部分患者中，手术后可能会复发。在这项回顾性研究中，我们试图评估使用99 mTc-HYNIC-TOC（99 mTc-hydrazinonicotinyl-Tyr 3-octreotide）的生长抑素受体显像是否也适用于初次成功手术后复发的TIO患者。方法回顾性分析18例可疑复发性TIO患者的99 mTc-HYNIC-TOC影像及临床资料。将影像学结果与临床图表进行比较，其中包括临床随访以及随后的影像学和手术。结果18例患者中，5例99 mTc-HYNIC-TOC显像阴性。在这5例影像学检查阴性的患者中，3例患者的复发症状和低磷血症的原因最终被发现与TIO无关。99 mTc-HYNIC-TOC对13例患者的同一部位复发性肿瘤（n = 10）或其他部位不同病因肿瘤（n = 3）进行了诊断，敏感性为86.7%（13/15）。结论99 mTc-HYNIC-TOC显像对潜在复发性TIO患者的评估效果与从未接受过罪犯肿瘤手术切除的新患者的评估效果一致。它可以在已知的TIO患者中发挥重要作用，这些患者被怀疑患有复发性疾病。
Purpose Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease. In small percentage of the patients, however, there can be recurrent disease after the surgery. In this retrospective investigation, we tried to assess whether somatostatin receptor imaging using 99mTc-HYNIC-TOC (99mTc-hydrazinonicotinyl-Tyr3-octreotide) is also useful in patients with recurrent TIO after initial successful surgery. Methods The images of 99mTc-HYNIC-TOC images and clinical charts of total 18 patients with suspected recurrent TIO were retrospectively reviewed. The image findings were compared with the clinical chart, which include clinical follow-up and subsequent imaging and surgery. Results Among all 18 patients, 99mTc-HYNIC-TOC imaging results were negative in 5 of them. Among these 5 patients with negative imaging study, the causes of recurrent symptoms and hypophosphatemia in 3 patients were eventually found unrelated to TIO. 99mTc-HYNIC-TOC successfully identified either recurrent causative tumors in the same location (n = 10) or different causative tumor in other locations (n = 3) in 13 patients, which rendered a sensitivity of 86.7% (13 of 15). Conclusions The efficacy of 99mTc-HYNIC-TOC imaging in the evaluation of patients with potential recurrent TIO is compatible to that with new patients who never received surgical resection for the culprit tumors. It can play an important role in known TIO patients who were suspected to have recurrent disease.
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影响因子：
10.6
作者：
Qiao He;Ze-qing Xu;Bing Zhang;Wanming Hu;Xiangsong Zhang
通讯作者：
Qiao He;Ze-qing Xu;Bing Zhang;Wanming Hu;Xiangsong Zhang
影响因子：
2.6
作者：
Sidell, Douglas;Lai, Chi;Chhetri, Dinesh K.
通讯作者：
Chhetri, Dinesh K.
影响因子：
5.5
作者：
Hofman, Michael S.;Lau, W. F. Eddie;Hicks, Rodney J.
通讯作者：
Hicks, Rodney J.
影响因子：
10.6
作者：
H. Jing;Fang Li;Dingrong Zhong;H. Zhuang
通讯作者：
H. Jing;Fang Li;Dingrong Zhong;H. Zhuang
影响因子：
8
作者：
Dupond, Jean-Louis;Mahammedi, Hakim;Kantelip, Bernadette
通讯作者：
Kantelip, Bernadette