Genomic islands: tools of bacterial horizontal gene transfer and evolution.
Genomic islands: tools of bacterial horizontal gene transfer and evolution.
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DOI：
10.1111/j.1574-6976.2008.00136.x
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发表时间：
2009-03
影响因子：
11.3
通讯作者：
Crook DW
中科院分区：
文献类型：
--
作者：
Juhas M;van der Meer JR;Gaillard M;Harding RM;Hood DW;Crook DW
细菌基因组通过突变、重排或水平基因转移进化。除了编码基本代谢功能的核心基因外，细菌基因组还含有许多通过水平基因转移获得的辅助基因，这些基因在某些环境条件下可能是有益的。水平基因转移有助于微生物的多样性和适应性，从而对基因组可塑性产生影响。水平基因转移的一个重要部分是或已经由基因组岛（GEI）促进。GEI是离散的DNA片段，其中一些是移动的，而另一些不是或不再是移动的，其在密切相关的菌株中不同。许多GEI能够整合到宿主的染色体中，切除，并通过转化、接合或转导转移到新的宿主。GEI在广谱细菌的进化中起着至关重要的作用，因为它们参与可变基因的传播，包括导致医院“超级细菌”产生的抗生素抗性和毒力基因，以及导致新代谢途径形成的分解代谢基因。根据基因模块的组成，相同类型的GEI可以促进致病菌和环境细菌的存活。
Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer. Besides the core genes encoding essential metabolic functions, bacterial genomes also harbour a number of accessory genes acquired by horizontal gene transfer that might be beneficial under certain environmental conditions. The horizontal gene transfer contributes to the diversification and adaptation of microorganisms, thus having an impact on the genome plasticity. A significant part of the horizontal gene transfer is or has been facilitated by genomic islands (GEIs). GEIs are discrete DNA segments, some of which are mobile and others which are not, or are no longer mobile, which differ among closely related strains. A number of GEIs are capable of integration into the chromosome of the host, excision, and transfer to a new host by transformation, conjugation or transduction. GEIs play a crucial role in the evolution of a broad spectrum of bacteria as they are involved in the dissemination of variable genes, including antibiotic resistance and virulence genes leading to generation of hospital ‘superbugs’, as well as catabolic genes leading to formation of new metabolic pathways. Depending on the composition of gene modules, the same type of GEIs can promote survival of pathogenic as well as environmental bacteria.
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影响因子：
4.4
作者：
Butler JE;He Q;Nevin KP;He Z;Zhou J;Lovley DR
通讯作者：
Lovley DR
影响因子：
64.8
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
柑橘相关木质固醇菌株的比较基因组表征。
影响因子：
4.4
作者：
da Silva, Vivian S;Shida, Claudio S;Rodrigues, Fabiana B;Ribeiro, Diogenes C D;de Souza, Alessandra A;Coletta-Filho, Helvecio D;Machado, Marcos A;Nunes, Luiz R;de Oliveira, Regina Costa
通讯作者：
de Oliveira, Regina Costa
影响因子：
3.2
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
4.9
作者：
Dimopoulou, ID;Russell, JE;Crook, DW
通讯作者：
Crook, DW