Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials
Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials
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对脊髓伤害感受的习得控制减少了脊髓上伤害感受，如晚期体感诱发电位所量化
DOI：
10.1097/j.pain.0000000000000327
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发表时间：
2015
期刊：
影响因子：
7.4
通讯作者：
A. Straube
中科院分区：
文献类型：
--
作者：
R. Ruscheweyh;M. Bäumler;M. Feller;S. Krafft;J. Sommer;A. Straube
摘要我们最近发现，受试者可以学习使用认知-情绪策略来抑制他们的脊髓伤害性屈肌反射（RIII反射）下的视觉RIII反馈，并提出，这反映了学习激活下行疼痛抑制。在这里，我们调查是否学习RIII抑制也影响脊髓上的伤害性感受，以及是否以前的放松训练增加成功。受试者接受了3次训练，通过自我选择的认知-情感策略来减少他们的RIII大小。两组接受真实的RIII反馈（有或没有以前的放松训练），假组接受虚假反馈（每组15名受试者）。记录RIII反射、晚期体感诱发电位（SEP）和F波，并收集疼痛强度评级。两个真实反馈组均实现了显著（P < 0.01）但相似的RIII抑制（至对照组的79% ± 21%和70% ± 17%）。体感诱发电位波幅（刺激后100-150毫秒）随RIII大小的增加而降低（r = 0.57，P < 0.01）。在假手术组中，在反馈训练期间，RIII大小和SEP振幅均未显著降低。3组患者的疼痛强度均显著降低，且与RIII降低相关（r = 0.44，P < 0.01）。在RIII抑制期间，F波参数不受影响。目前的研究结果表明，学习RIII抑制也会影响脊髓上的伤害性感受量化的SEP，虽然对疼痛评级的影响不太清楚。由F波量化的下运动神经元兴奋性不受影响。先前的放松训练并没有显著提高RIII反馈训练的成功率。
Abstract We have recently shown that subjects can learn to use cognitive-emotional strategies to suppress their spinal nociceptive flexor reflex (RIII reflex) under visual RIII feedback and proposed that this reflects learned activation of descending pain inhibition. Here, we investigated whether learned RIII suppression also affects supraspinal nociception and whether previous relaxation training increases success. Subjects were trained over 3 sessions to reduce their RIII size by self-selected cognitive-emotional strategies. Two groups received true RIII feedback (with or without previous relaxation training) and a sham group received false feedback (15 subjects per group). RIII reflexes, late somatosensory evoked potentials (SEPs), and F-waves were recorded and pain intensity ratings collected. Both true feedback groups achieved significant (P < 0.01) but similar RIII suppression (to 79% ± 21% and 70% ± 17% of control). Somatosensory evoked potential amplitude (100-150 milliseconds after stimulation) was reduced in parallel with the RIII size (r = 0.57, P < 0.01). In the sham group, neither RIII size nor SEP amplitude was significantly reduced during feedback training. Pain intensity was significantly reduced in all 3 groups and also correlated with RIII reduction (r = 0.44, P < 0.01). F-wave parameters were not affected during RIII suppression. The present results show that learned RIII suppression also affects supraspinal nociception as quantified by SEPs, although effects on pain ratings were less clear. Lower motor neuron excitability as quantified by F-waves was not affected. Previous relaxation training did not significantly improve RIII feedback training success.
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SEP 地形由无害和有害的腓肠神经刺激引起。
DOI：
10.1016/0168-5597(94)90097-3
发表时间：
1994
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Dowman,R
通讯作者：
Dowman,R
SEP 地形由无害和有害的腓肠神经刺激引起。
DOI：
10.1016/0168-5597(94)90098-1
发表时间：
1994
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Dowman,R
通讯作者：
Dowman,R
SEP 地形由无害和有害的腓肠神经刺激引起。
DOI：
10.1016/0168-5597(94)90014-0
发表时间：
1994
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Dowman,R;Darcey,TM
通讯作者：
Darcey,TM
影响因子：
3.7
作者：
Dowman, R
通讯作者：
Dowman, R