Anisotropic composite material phantom to improve skeletal muscle characterization using magnetic resonance elastography.
Anisotropic composite material phantom to improve skeletal muscle characterization using magnetic resonance elastography.
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DOI：
10.1016/j.jmbbm.2018.09.032
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发表时间：
2019-01
影响因子：
3.9
通讯作者：
Royston TJ
中科院分区：
文献类型：
--
作者：
Guidetti M;Lorgna G;Hammersly M;Lewis P;Klatt D;Vena P;Shah R;Royston TJ
神经肌肉病理学的存在和进展，包括痉挛、杜氏肌营养不良症和甲状腺功能亢进症，与骨骼肌组织内在机械特性的变化相关。用于无创测量和监测这些特性的工具，例如磁共振弹性成像（MRE），可以通过提供评估和跟踪疗效的方法，有利于理解神经肌肉病理学的基础研究，以及开发疗法的转化研究。用于无创测量组织机械性能的动态弹性成像方法已经开发了近三十年。迄今为止，基于超声 (US) 和基于磁共振成像 (MRI) 的策略的大部分技术发展都是基于局部均匀性和各向同性的假设。横纹骨骼肌和心肌，以及其他一些器官区域的脑白质和软组织，表现出纤维微观结构，导致异质性和各向异性反应；当人们寻求提高机械性能评估的准确性和分辨率时，需要考虑异质性和各向异性，以优化动态弹性成像实验方案和测量结果的解释。弹性成像方法在每一步的进步都得益于模拟组织模型的使用。本研究的目的是开发和表征具有均匀可控各向异性特性的异质复合模型设计，该特性可与骨骼肌的频率相关各向异性特性相媲美。对新型 3D 打印复合模型设计进行了 MRE 实验和计算有限元 (FE) 研究。从模拟和实验获得的位移图显示相同的椭圆形波前在结构呈现更高剪切模量的平面中拉长。该模型表现出一定程度的各向异性，与骨骼肌组织 MRE 实验的文献数据一致。 MRE 实验的有限元模拟可以深入了解实验测量的正确解释，并有助于量化不同尺度各向异性材料中异质性的重要性。
The presence and progression of neuromuscular pathology, including spasticity, Duchenne’s muscular dystrophy and hyperthyroidism, has been correlated with changes in the intrinsic mechanical properties of skeletal muscle tissue. Tools for noninvasively measuring and monitoring these properties, such as Magnetic Resonance Elastography (MRE), could benefit basic research into understanding neuromuscular pathologies, as well as translational research to develop therapies, by providing a means of assessing and tracking their efficacy. Dynamic elastography methods for noninvasive measurement of tissue mechanical properties have been under development for nearly three decades. Much of the technological development to date, for both Ultrasound (US)-based and Magnetic Resonance Imaging (MRI)-based strategies, has been grounded in assumptions of local homogeneity and isotropy. Striated skeletal and cardiac muscle, as well as brain white matter and soft tissue in some other organ regions, exhibit a fibrous microstructure which entails heterogeneity and anisotropic response; as one seeks to improve the accuracy and resolution in mechanical property assessment, heterogeneity and anisotropy need to be accounted for in order to optimize both the dynamic elastography experimental protocol and the interpretation of the measurements. Advances in elastography methodology at every step have been aided by the use of tissue-mimicking phantoms. The aim of the present study was to develop and characterize a heterogeneous composite phantom design with uniform controllable anisotropic properties meant to be comparable to the frequency-dependent anisotropic properties of skeletal muscle. MRE experiments and computational finite element (FE) studies were conducted on a novel 3D-printed composite phantom design. The displacement maps obtained from simulation and experiment show the same elliptical shaped wavefronts elongated in the plane where the structure presents higher shear modulus. The model exhibits a degree of anisotropy in line with literature data from skeletal muscle tissue MRE experiments. FE simulations of the MRE experiments provide insight into proper interpretation of experimental measurements, and help to quantify the importance of heterogeneity in the anisotropic material at different scales.
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影响因子：
4.3
作者：
Basford, JR;Jenkyn, TR;Kaufman, KR
通讯作者：
Kaufman, KR
影响因子：
2.9
作者：
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Bilston, L. E.
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