Usefulness of Plasma Vascular Endothelial Growth Factor in the Diagnosis of Pancreatic Carcinoma: Differential Diagnosis, Tumor Progression, and Patient Survival
Usefulness of Plasma Vascular Endothelial Growth Factor in the Diagnosis of Pancreatic Carcinoma: Differential Diagnosis, Tumor Progression, and Patient Survival
复制标题
血浆血管内皮生长因子在胰腺癌诊断中的用途：鉴别诊断、肿瘤进展和患者生存
作者：
A. Kobayashi;Taketo Yamaguchi;T. Ishihara;Tadashi Ohshima;Takeshi Baba;Y. Shirai;H. Tadenuma;Kazuyoshi Nakamura;H. Saisho
目的：本研究旨在探讨胰腺癌（PC）患者血浆血管内皮生长因子（p-VEGF）作为PC肿瘤标志物的有效性，并与慢性胰腺炎（CP）进行比较，以阐明p-VEGF与PC临床病理特征的关系。方法：选择69例PC患者、35例CP患者和26例健康志愿者作为对照组。采用酶联免疫法检测p-VEGF水平。结果：PC组p-VEGF水平显著高于CP组和对照组（P < 0.0001）。基于受试者工作特征曲线确定了区分PC和CP的临界水平149.5 pg/mL。使用该临界值，敏感性为60%，特异性为96%，准确性为73%。有远处转移者p-VEGF水平显著高于无远处转移者（P = 0.0113）。多因素分析显示高水平p-VEGF是独立的预后因素，p-VEGF与中位生存时间显著相关（P = 0.0092）。结论：p-VEGF在PC和CP的鉴别诊断中有一定的价值，在PC患者中，高水平的p-VEGF可能是远处转移和预后不良的预测因子。
Objectives: This study aimed to examine the usefulness of plasma vascular endothelial growth factor (p-VEGF) in patients with pancreatic carcinoma (PC) as a tumor marker for PC in comparison with chronic pancreatitis (CP) and to clarify the relationship between p-VEGF and the clinicopathological features of PC. Methods: The subjects were 69 patients with PC, 35 with CP, and 26 healthy volunteers (control group). The p-VEGF levels were measured by enzyme-linked immunoassay. Results: p-VEGF levels were significantly higher in the PC group compared with the CP and control groups (P < 0.0001). A cut-off level of 149.5 pg/mL, discriminating between PC and CP, was determined based on a receiver operating characteristic curve. Using this cut-off level, the sensitivity was 60%, specificity was 96%, and accuracy was 73%. Patients with PC with distant metastases exhibited a significantly higher level of p-VEGF compared with those without metastasis (P = 0.0113). Multivariate analysis indicated that a high level of p-VEGF was an independent prognostic factor, and a significant association was observed between p-VEGF and median survival time (P = 0.0092). Conclusions: p-VEGF proved useful in differentiating between PC and CP, and in patients with PC, a high level of p-VEGF may be a predictor of distant metastases and poor prognosis.
影响因子：
3.8
作者：
Oh, Sung Yong;Kwon, Hyuk-Chan;Kim, Sung-Hyun;Jang, Jin Seok;Kim, Min Chan;Kim, Kyeong Hee;Han, Jin-Yeong;Kim, Chung Ock;Kim, Su-Jin;Jeong, Jin-sook;Kim, Hyo-Jin
通讯作者：
Kim, Hyo-Jin