Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer.
Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer.
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DOI：
10.1186/1471-2407-8-123
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发表时间：
2008-05-01
期刊：
影响因子：
3.8
通讯作者：
Kim, Hyo-Jin
中科院分区：
文献类型：
--
作者：
Oh, Sung Yong;Kwon, Hyuk-Chan;Kim, Sung-Hyun;Jang, Jin Seok;Kim, Min Chan;Kim, Kyeong Hee;Han, Jin-Yeong;Kim, Chung Ock;Kim, Su-Jin;Jeong, Jin-sook;Kim, Hyo-Jin
缺氧通过诱导血管生成和遗传改变来影响肿瘤生长。缺氧诱导因子1α（HIF-1α）、p53和血管内皮生长因子（VEGF）都是肿瘤进展固有机制中的重要因素。本研究旨在探讨HIF-1α、p53、VEGF在胃癌中的表达及术前血清VEGF（sVEGF）水平的临床病理意义。我们采用免疫组化方法检测了114例胃癌组织中HIF-1α、p53和VEGF的表达。此外，我们还测定了术前血清VEGF（sVEGF）水平。p53和HIF-1α（弥漫型、深部型、血管内型）的阳性率分别为38.6%和15.8%。VEGF过表达率为57.9%。p53和HIF-1α与胃癌浸润深度呈正相关（P = 0.015，P = 0.001）。术前sVEGF和p53水平与淋巴结转移显著相关（分别为P = 0.010和P = 0.040）。老年组（≥ 60岁）和肠型组中VEGF过表达更频繁（分别为P = 0.013、P = 0.014）。但未观察到术前sVEGF水平与组织HIF-1α、VEGF和p53之间的相关性。术后中位随访时间为24.5个月。HIF-1α是疾病复发或进展的不良预后因素（P = 0.002）。p53、HIF-1α和术前sVEGF可作为判断胃癌浸润深度或淋巴结转移的指标。HIF-1α的表达是胃癌复发或进展的不良预后因素。
Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF (sVEGF) level in gastric cancer. We immunohistochemically assessed the HIF-1α, p53, and VEGF expression patterns in 114 specimens of gastric cancer. Additionally, we determined the levels of preoperative serum VEGF (sVEGF). The positive rates of p53 and HIF-1α (diffuse, deep, intravascular pattern) were 38.6% and 15.8%, respectively. The VEGF overexpression rate was 57.9%. p53 and HIF-1α were correlated positively with the depth of invasion (P = 0.015, P = 0.001, respectively). Preoperative sVEGF and p53 levels were correlated significantly with lymph node involvement (P = 0.010, P = 0.040, respectively). VEGF overexpression was more frequently observed in the old age group (≥ 60 years old) and the intestinal type (P = 0.013, P = 0.014, respectively). However, correlations between preoperative sVEGF level and tissue HIF-1α, VEGF, and p53 were not observed. The median follow-up duration after operation was 24.5 months. HIF-1α was observed to be a poor prognostic factor of disease recurrence or progression (P = 0.002). p53, HIF-1α and preoperative sVEGF might be markers of depth of invasion or lymph node involvement. HIF-1α expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers.
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影响因子：
3
作者：
Hashimoto, H;Akimoto, M;Yamashito, K
通讯作者：
Yamashito, K
影响因子：
8.8
作者：
Fondevila, C;Metges, J P;Fuster, J;Grau, J J;Palacin, A;Castells, A;Volant, A;Pera, M
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Pera, M
影响因子：
9.7
作者：
Nakayama, K;Kanzaki, A;Takebayashi, Y
通讯作者：
Takebayashi, Y
影响因子：
5.7
作者：
Konno, H;Ohta, M;Nakamura, S
通讯作者：
Nakamura, S
影响因子：
1.6
作者：
Baba, M;Konno, H;Baba, S
通讯作者：
Baba, S