Impact of Diabetes Mellitus on Early Clinical Outcome and Stent Restenosis after Carotid Artery Stenting.
Impact of Diabetes Mellitus on Early Clinical Outcome and Stent Restenosis after Carotid Artery Stenting.
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DOI：
10.1155/2022/4196195
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发表时间：
2022
影响因子：
4.3
通讯作者：
Ruzsa, Zoltan
中科院分区：
文献类型：
--
作者：
Achim, Alexandru;Lacko, David;Huettl, Artur;Csobay-Novak, Csaba;Csavajda, Adam;Sotonyi, Peter;Merkely, Bela;Nemes, Balazs;Ruzsa, Zoltan
糖尿病与颈动脉疾病的严重程度及其血运重建后的结局密切相关。颈动脉支架植入术（CAS）已成为外科动脉内膜切除术的可行替代方案，但对CAS后糖尿病的影响知之甚少。 在两个研究机构接受CAS的1940例患者的连续队列被分为两组，糖尿病患者和非糖尿病患者，并在CAS后30天和1年随访时分析主要脑血管事件（MACCE）。 有730例糖尿病患者，BMI、高血压、慢性透析和血脂异常频率显著较高（p < 0.05）。两组之间的早期和晚期MACCE（短暂性脑缺血发作、严重中风、心肌梗死和死亡的复合）没有显着差异，12个月时的早期发生率为3.5%非糖尿病患者vs. 5.3%，p = 0.08，非糖尿病患者vs. 2.3%糖尿病患者，p = 0.1。无症状患者的总体中风/死亡率为2.4%，糖尿病人群的再狭窄率更高（2.3%与1%，p = 0.04）。 糖尿病的存在与CAS的围手术期风险增加可接受相关，但在长期随访期间未出现进一步的额外风险。糖尿病可加速早期支架内再狭窄的发生率。
Diabetes mellitus is closely related to both the severity of carotid disease and its outcome after revascularization. Carotid artery stenting (CAS) has emerged as a viable alternative to surgical endarterectomy but little is known about the impact of diabetes after CAS. A consecutive cohort of 1940 patients undergoing CAS in two institutions was divided into two groups, diabetics and nondiabetics, and major cerebrovascular events (MACCEs) were analyzed at 30 days post-CAS and at 1 year follow-up. There were 730 patients with diabetes, with significantly higher BMI, hypertension, chronic dialysis, and dyslipidemia frequency (p < 0.05). There was no significant difference between the two groups in terms of early and late MACCEs (composite of transient ischemic attack, major stroke, myocardial infarction, and death), with an early rate of 3.5% nondiabetics vs. 5.3%, p = 0.08 and 2.4 nondiabetics vs. 2.3% diabetics, p = 0.1 at 12 months. Overall stroke/death rate in the asymptomatic patients was 2.4%, and the restenosis rate was higher in the diabetes population (2.3% vs. 1%, p = 0.04). The presence of diabetes was associated with an acceptable increased periprocedural risk for CAS, but no further additional risk emerged during longer term follow-up. Diabetes may precipitate the rate of early in-stent restenosis.
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影响因子：
3.5
作者：
Lacroix, P.;Aboyans, V.;Laskar, M.
通讯作者：
Laskar, M.
DOI：
10.1056/nejmoa0912321
发表时间：
2010-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brott TG;Hobson RW 2nd;Howard G;Roubin GS;Clark WM;Brooks W;Mackey A;Hill MD;Leimgruber PP;Sheffet AJ;Howard VJ;Moore WS;Voeks JH;Hopkins LN;Cutlip DE;Cohen DJ;Popma JJ;Ferguson RD;Cohen SN;Blackshear JL;Silver FL;Mohr JP;Lal BK;Meschia JF;CREST Investigators
通讯作者：
CREST Investigators
DOI：
10.1016/s0140-6736(21)01910-3
发表时间：
2021-09-18
期刊：
Lancet (London, England)
影响因子：
--
作者：
Halliday A;Bulbulia R;Bonati LH;Chester J;Cradduck-Bamford A;Peto R;Pan H;ACST-2 Collaborative Group
通讯作者：
ACST-2 Collaborative Group
影响因子：
3.9
作者：
Achim A;Kákonyi K;Jambrik Z;Nagy F;Tóth J;Sasi V;Hausinger P;Nemes A;Varga A;Bertrand OF;Ruzsa Z
通讯作者：
Ruzsa Z
影响因子：
3.6
作者：
通讯作者：
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