Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.
Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.
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DOI：
10.1002/1873-3468.13781
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发表时间：
2020-12
期刊：
影响因子：
3.5
通讯作者：
Godzik A
中科院分区：
文献类型：
--
作者：
Porta-Pardo E;Valencia A;Godzik A
癌症生物学的关键挑战之一是分类和理解导致癌症的体细胞基因组改变。尽管已经开发了替代定义和搜索方法来识别癌症驱动基因和突变，但对数千个癌症基因组的分析返回了至少一种癌症类型中突变的约300个基因的非常相似的目录。然而，这些基因的许多特征及其在癌症中的作用仍然不清楚，首先是当体细胞突变真正致癌时。在这篇综述中，我们首先总结了最近在完成癌症驱动基因目录方面所做的一些努力。然后，我们概述了影响核心癌症驱动基因中体细胞突变致癌性的不同方面，包括它们与种系基因组的相互作用，其他癌症驱动突变，免疫系统或它们在健康组织中的潜在作用。在未来几年，这项研究有望阐明癌症驱动基因和突变如何、何时以及为什么是真正的驱动因素，从而推动个性化癌症药物和靶向治疗向前发展。
One of the key challenges of cancer biology is to catalogue and understand the somatic genomic alterations leading to cancer. Although alternative definitions and search methods have been developed to identify cancer driver genes and mutations, analyses of thousands of cancer genomes return a remarkably similar catalogue of around 300 genes that are mutated in at least one cancer type. Yet, many features of these genes and their role in cancer remain unclear, first and foremost when a somatic mutation is truly oncogenic. In this review, we first summarize some of the recent efforts in completing the catalogue of cancer driver genes. Then, we give an overview of different aspects that influence the oncogenicity of somatic mutations in the core cancer driver genes, including their interactions with the germline genome, other cancer driver mutations, the immune system, or their potential role in healthy tissues. In the coming years, this research holds promise to illuminate how, when, and why cancer driver genes and mutations are really drivers, and thereby move personalized cancer medicine and targeted therapies forward.
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在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
50.3
作者：
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通讯作者：
Boehm JS
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
12.3
作者：
Bashashati A;Haffari G;Ding J;Ha G;Lui K;Rosner J;Huntsman DG;Caldas C;Aparicio SA;Shah SP
通讯作者：
Shah SP
影响因子：
12.3
作者：
Cho A;Shim JE;Kim E;Supek F;Lehner B;Lee I
通讯作者：
Lee I