Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications.
Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications.
复制标题
偏斜的表观遗传学：糖尿病并发症的替代治疗选择。
DOI：
10.1155/2015/373708
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发表时间：
2015
影响因子：
4.3
通讯作者：
Brizzi MF
中科院分区：
文献类型：
--
作者：
Togliatto G;Dentelli P;Brizzi MF
血管并发症是2型糖尿病患者发病和死亡的主要原因。高血糖导致的线粒体活性氧（ROS）的产生和有效抗氧化机制的缺乏是导致这一问题的主要原因。尽管治疗的进步显着降低了糖尿病患者的发病率和死亡率，但糖尿病相关的血管并发症仍然是全球最具挑战性的健康问题之一。由于当前的治疗方法无法改善长期结果，因此迫切需要新的治疗方案。最近，人们特别致力于了解染色质结构调节与基因表达持续变化之间的功能关系，这种变化是由高血糖驱动的，也是长期糖尿病并发症的原因。关于 2 型糖尿病表观遗传染色质修饰的详细研究正在进行中。这对于设计基于机制的疗法特别有用，这些疗法会干扰持久的激活表观遗传学并改善患者的治疗结果。我们在此概述了解释高血糖引起的染色质结构变化的最相关机制；最相关的机制称为“代谢记忆”。
Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. Although advances in therapy have significantly reduced both morbidity and mortality in diabetic individuals, diabetes-associated vascular complications are still one of the most challenging health problems worldwide. New healing options are urgently needed as current therapeutics are failing to improve long-term outcomes. Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. A detailed investigation into epigenetic chromatin modifications in type 2 diabetes is underway. This will be particularly useful in the design of mechanism-based therapeutics which interfere with long-lasting activating epigenetics and improve patient outcomes. We herein provide an overview of the most relevant mechanisms that account for hyperglycaemia-induced changes in chromatin structure; the most relevant mechanism is called “metabolic memory.”
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