MicroRNAs: potential mediators and biomarkers of diabetic complications.
MicroRNAs: potential mediators and biomarkers of diabetic complications.
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DOI：
10.1016/j.freeradbiomed.2013.06.009
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发表时间：
2013-09
影响因子：
7.4
通讯作者：
Natarajan, Rama
中科院分区：
文献类型：
--
作者：
Kato, Mitsuo;Castro, Nancy E.;Natarajan, Rama
糖尿病的发病率在全球范围内不断上升，因此，这已成为一个主要的医疗保健问题。此外，1型和2型糖尿病都与微血管并发症(包括视网膜病变、肾病和神经病变)以及大血管并发症(如动脉粥样硬化性心血管疾病和高血压疾病)的发生率显著加快有关。导致这些并发症的关键因素包括高血糖、胰岛素抵抗、血脂异常、晚期糖基化终末产物、生长因子、炎性细胞因子/趋化因子以及相关的细胞氧化应激(包括线粒体)和内质网应激增加。然而，糖尿病并发症的高发病率背后的分子机制，往往进展，尽管血糖控制，仍然没有完全了解。MicroRNAs(MiRNAs)是一种短小的非编码RNA，近年来引起了极大的兴趣。它们通过转录后机制抑制靶基因的表达，具有不同的细胞和生物学功能。在此，我们讨论了miRNAs在各种糖尿病并发症的病理生物学中的作用，它们在氧化应激中的作用，以及差异表达的miRNAs作为新的诊断生物标志物和治疗靶点的潜在用途。
The incidence of diabetes is escalating worldwide and consequently, this has become a major healthcare problem. Moreover, both type 1 and type 2 diabetes are associated with significantly accelerated rates of microvascular complications including retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as atherosclerotic cardiovascular and hypertensive diseases. Key factors have been implicated in leading to these complications including hyperglycemia, insulin resistance, dyslipidemia, advanced glycation end products, growth factors, inflammatory cytokines/chemokines and related increases in cellular oxidant stress (including mitochondrial) and endoplasmic reticulum stress. However, the molecular mechanisms underlying the high incidence of diabetic complications, which often progress despite glycemic control, are still not fully understood. MicroRNAs (miRNAs) are short non-coding RNAs that have elicited immense interest in recent years. They repress target gene expression via post-transcriptional mechanisms and have diverse cellular and biological functions. Herein, we have discussed the role of miRNAs in the pathobiology of various diabetic complications, their involvement in oxidant stress, and also the potential use of differentially expressed miRNAs as novel diagnostic biomarkers and therapeutic targets.
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影响因子：
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作者：
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通讯作者：
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10.1073/pnas.0710228105
发表时间：
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影响因子：
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