Non-Celiac Gluten Sensitivity: An Update.
Non-Celiac Gluten Sensitivity: An Update.
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DOI：
10.3390/medicina57060526
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发表时间：
2021-05-24
期刊：
影响因子：
--
通讯作者：
Ontiveros N
中科院分区：
文献类型：
--
作者：
Cárdenas-Torres FI;Cabrera-Chávez F;Figueroa-Salcido OG;Ontiveros N
非乳糜泻谷蛋白敏感性（NCGS）是一种临床实体，其特征在于患者中没有乳糜泻和小麦过敏，这些过敏触发对含谷蛋白食物消费的可再现症状反应。由于缺乏用于NCGS诊断的敏感和可重复的生物标志物，因此必须进行安慰剂对照的谷蛋白激发以用于其诊断。谷蛋白挑战可以是双盲或单盲的，分别用于研究或临床实践目的。为了提高我们对不同人群中NCGS的程度和相关性的理解，已经进行了基于自我报告的流行病学研究。然而，基于麸质挑战的NCGS患病率仍有待估计。由于NCGS最近被认为是一种临床实体，因此需要更多的研究来深入研究NCGS的发病机制，例如，引发NCGS的可疑谷物成分之间的分子相互作用，如可发酵的寡糖，二糖，单糖和多元醇（FODMAPs）以及淀粉酶和胰蛋白酶抑制剂，免疫系统仍有待阐明。虽然仍在争论中，但NCGS患者可能仅对一种或多种NCGS触发因素敏感。NCGS的治疗涉及对疾病的疑似触发因素进行饮食限制，但关于不同饮食干预措施（如无麸质饮食和低FODMAP饮食）的有效性存在争议。当然，我们对NCGS的理解正在迅速提高，因为关于这个主题的新科学信息不断涌现。因此，本叙述性综述的目的是对NCGS从流行病学到当前治疗进行最新概述。
Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by the absence of celiac disease and wheat allergy in patients that trigger reproducible symptomatic responses to gluten-containing foods consumption. Due to the lack of sensitive and reproducible biomarkers for NCGS diagnosis, placebo-controlled gluten challenges must be carried out for its diagnosis. The gluten challenges can be either double- or single-blind, for research or clinical practice purposes, respectively. For improving our understanding about the magnitude and relevance of NCGS in different populations, epidemiological studies based on self-report have been carried out. However, the gluten challenge-based prevalence of NCGS remains to be estimated. Since NCGS was recently recognized as a clinical entity, more studies are needed to delve into NCGS pathogenesis, for instance, the molecular interactions between the suspected cereal grain components that trigger NCGS, such as fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) and amylase and trypsin inhibitors, and the immune system remains to be elucidated. Although still under debate, NCGS patients can be susceptible to only one or more than one of the NCGS triggers. The treatment of NCGS involves the dietary restriction of the suspected triggers of the disease, but there is controversial data about the effectiveness of different dietary interventions such as the gluten-free diet and low-FODMAP diet. Certainly, our understanding of NCGS is improving quickly due to the constant availability of new scientific information on this topic. Thus, the aim of the present narrative review is to present an up-to-date overview on NCGS from epidemiology to current therapy.
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影响因子：
2
作者：
Cabrera-Chavez, Francisco;Maria Granda-Restrepo, Diana;Ontiveros, Noe
通讯作者：
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DOI：
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发表时间：
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