Association of Radiation Dose to the Amygdala-Orbitofrontal Network with Emotion Recognition Task Performance in Patients with Low-Grade and Benign Brain Tumors.
Association of Radiation Dose to the Amygdala-Orbitofrontal Network with Emotion Recognition Task Performance in Patients with Low-Grade and Benign Brain Tumors.
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低度良性脑肿瘤患者杏仁核-眶额网络的辐射剂量与情绪识别任务表现的关系。
DOI：
10.3390/cancers15235544
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发表时间：
2023-11-23
期刊：
影响因子：
5.2
通讯作者：
Janelsins, Michelle
中科院分区：
文献类型：
--
作者：
Hardy, Sara J.;Finkelstein, Alan;Milano, Michael T.;Schifitto, Giovanni;Sun, Hongying;Holley, Koren;Usuki, Kenneth;Weber, Miriam T.;Zheng, Dandan;Seplaki, Christopher L.;Janelsins, Michelle
关键词：
脑肿瘤患者经常会经历记忆和思维其他方面的变化。许多人也可能在社会认知方面有困难，影响促进社会行为和维持社会关系的能力;然而，数据有限。颅辐射等治疗是否会影响社会认知还没有得到很好的研究。我们试图了解辐射剂量暴露于杏仁核眶额神经网络，这有助于社会认知和情绪识别，影响情绪识别任务的表现。我们发现，杏仁核和相关结构的辐射剂量与情绪识别任务的表现有关，包括随着辐射剂量的增加而延长的反应时间。减少杏仁核-眶额网络剂量的放射技术可能会减少接受颅放射的患者的副作用。背景：尽管数据有限，但高达83%的脑肿瘤患者存在社会认知困难。目前尚不清楚杏仁核-眶额网络的颅放射治疗（RT）剂量是否会影响社会认知。研究方法：我们前瞻性地招募了51例低度恶性和良性脑肿瘤患者，计划进行颅脑RT。我们评估了情绪识别任务（ERT）的纵向变化，该任务通过显示表达六种基本情绪的面孔及其与杏仁核-眶额网络RT剂量的相关性来衡量识别情绪状态的能力。ERT结局包括选择反应（ERTOMDRT）或正确反应（ERTOMDCRT）的中位时间和总正确反应（ERTHH）。结果：杏仁核-眶额网络的RT剂量与ERT的中位反应时间较长显著相关。中位反应时间的增加发生在较低剂量下，而不是总正确反应的减少。内侧眶额皮质是回归树预测ERTOMDCRT变化的最重要变量。讨论内容：据我们所知，这是第一个研究表明，脱靶RT剂量的杏仁核眶额网络与性能的社会认知任务，认知的一个方面，以前没有被机械研究后，颅RT。
Patients with brain tumors often experience changes in memory and other aspects of thinking. Many may also have difficulty with social cognition, affecting the abilities that facilitate social behavior and maintain social relationships; however, the data are limited. Whether treatments such as cranial radiation can impact social cognition is not well-studied. We sought to understand how radiation dose exposure to the amygdala–orbitofrontal network, which subserves social cognition and emotion recognition, impacted performance on an emotion recognition task. We found that radiation dose to the amygdala and associated structures was associated with performance on an emotion recognition task, including longer response times with increasing radiation doses. Radiation techniques that reduce the dose to the amygdala-orbitofrontal network may decrease side effects for patients receiving cranial radiation. Background: Although data are limited, difficulty in social cognition occurs in up to 83% of patients with brain tumors. It is unknown whether cranial radiation therapy (RT) dose to the amygdala–orbitofrontal network can impact social cognition. Methods: We prospectively enrolled 51 patients with low-grade and benign brain tumors planned for cranial RT. We assessed longitudinal changes on an emotion recognition task (ERT) that measures the ability to recognize emotional states by displaying faces expressing six basic emotions and their association with the RT dose to the amygdala–orbitofrontal network. ERT outcomes included the median time to choose a response (ERTOMDRT) or correct response (ERTOMDCRT) and total correct responses (ERTHH). Results: The RT dose to the amygdala–orbitofrontal network was significantly associated with longer median response times on the ERT. Increases in median response times occurred at lower doses than decreases in total correct responses. The medial orbitofrontal cortex was the most important variable on regression trees predicting change in the ERTOMDCRT. Discussion: This is, to our knowledge, the first study to show that off-target RT dose to the amygdala–orbitofrontal network is associated with performance on a social cognition task, a facet of cognition that has previously not been mechanistically studied after cranial RT.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1158/1078-0432.ccr-11-2903
发表时间：
2013-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Greene-Schloesser D;Moore E;Robbins ME
通讯作者：
Robbins ME
影响因子：
16.2
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
15.9
作者：
Campanella, Fabio;Fabbro, Franco;Skrap, Miran
通讯作者：
Skrap, Miran
影响因子：
3.9
作者：
Goebel, Simone;Mehdorn, H. Maximilian;Wiesner, Christian D.
通讯作者：
Wiesner, Christian D.