microRNA regulation of synaptic plasticity.
microRNA regulation of synaptic plasticity.
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DOI：
10.1007/s12017-009-8065-2
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发表时间：
2009
影响因子：
3.5
通讯作者：
Lugli, Giovanni
中科院分区：
文献类型：
--
作者：
Smalheiser, Neil R.;Lugli, Giovanni
microrna在调节突触可塑性中发挥重要作用。例如，microrna靶向（并被靶向）可塑性介质，如CREB、MECP2和FMRP。此外，特定的microrna已被证明在树突内表达，在那里它们调节介导树突生长的靶蛋白翻译。RISC机制的组成部分与果蝇的长期记忆有关。在这里，我们回顾了来自成年小鼠前脑研究的证据，支持一个模型，其中突触刺激（高于阈值）增加树突棘内的钙，激活钙蛋白酶，并激活和释放突触后密度的dicer。Dicer将局部pre- mir加工成成熟的mirna，这些mirna被纳入树突棘内或附近的RISC复合物中，并结合附近可用的靶mrna。这些可能在静息条件下抑制蛋白质翻译，但允许翻译的阶段性爆发在随后的突触活动后短暂发生。负载的RISC复合物不与局部mrna结合，可以结合并捕获沿树突运输的mrna。因此，局部形成的microrna可能标记先前激活的突触的位置，并执行一种突触标记和捕获。
microRNAs play an important role in regulating synaptic plasticity. For example, microRNAs target (and are targeted by) plasticity mediators such as CREB, MECP2, and FMRP. As well, specific microRNAs have been shown to be expressed within dendrites, where they regulate protein translation of targets mediating dendritic growth. Components of the RISC machinery have been implicated in long-term memory in Drosophila. Here, we review evidence from studies of adult mouse forebrain supporting a model wherein synaptic stimulation (above a threshold value) increases calcium within dendritic spines, activates calpain, and activates and releases dicer from the postsynaptic density. Dicer processes local pre-miRs into mature miRNAs that are incorporated into RISC complexes within or near the dendritic spine, and that bind available target mRNAs in the vicinity. These may repress protein translation under resting conditions, yet permit a phasic burst of translation to occur transiently following subsequent synaptic activity. Loaded RISC complexes that are not bound to local mRNAs may serve to bind and trap mRNAs that are being transported down dendrites. Thus, locally formed microRNAs may mark the location of previously activated synapses and perform a type of synaptic tagging and capture.
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影响因子：
4.7
作者：
Lugli, G;Larson, J;Smalheiser, NR
通讯作者：
Smalheiser, NR
DOI：
10.1016/j.bbagrm.2008.10.002
发表时间：
2009-02-01
影响因子：
4.7
作者：
Dincbas-Renqvist, Vildan;Pepin, Genevieve;Provost, Patrick
通讯作者：
Provost, Patrick
影响因子：
4.5
作者：
Kye, Min-Jeong;Liu, Tsunglin;Kosik, Kenneth S.
通讯作者：
Kosik, Kenneth S.
影响因子：
64.5
作者：
Ashraf, SI;McLoon, AL;Kunes, S
通讯作者：
Kunes, S
大脑表达的microRNA与精神分裂症病因有关。
影响因子：
3.7
作者：
Hansen, Thomas;Olsen, Line;Lindow, Morten;Jakobsen, Klaus D.;Ullum, Henrik;Jonsson, Erik;Andreassen, Ole A.;Djurovic, Srdjan;Melle, Ingrid;Agartz, Ingrid;Hall, Hakan;Timm, Sally;Wang, August G.;Werge, Thomas
通讯作者：
Werge, Thomas