The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress.
The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress.
复制标题
DOI：
10.1016/j.pcl.2020.07.013
复制
发表时间：
2020-12
影响因子：
2.6
通讯作者：
Armstrong GT
中科院分区：
文献类型：
--
作者：
Dixon SB;Chow EJ;Hjorth L;Hudson MM;Kremer LCM;Morton LM;Nathan PC;Ness KK;Oeffinger KC;Armstrong GT
1975年，Giulio D'Angio指出“治愈是不够的”，并宣布后期效应研究是一个重要的优先事项。[1]如前几章所述，全球儿童癌症幸存者人数不断增加，他们在成年后面临着独特的健康和心理社会挑战，这是他们之前接受癌症治疗的结果。数十年的研究已经描述了幸存者经历的长期和晚期健康结果，包括特定治疗暴露、人口统计学和生活方式因素带来的风险。2-6然而，癌症生存率研究的未来必须集中在新的方法来识别，预防和减轻癌症治疗的不良反应。还应注意在不同的临床环境中传播和实施统一和具有成本效益的以患者为中心的生存护理。为了做到这一点，未来的研究重点必须包括多学科和国际合作的方法，以更好地了解新药物的毒性，遗传因素和衰老对晚期效应的贡献，干预目标，以及卫生服务研究和实施科学的作用，以确保普遍获得循证和全面的生存护理。
In 1975 Giulio D’Angio stated that “cure is not enough” and late effects research was declared an essential priority. 1 As detailed in the preceding chapters, there is a growing, global population of childhood cancer survivors who face unique health and psychosocial challenges in adulthood as a result of their prior cancer treatment. Decades of studies have described the long-term and late health outcomes experienced by survivors including risks conferred by specific therapy exposures, demographic and lifestyle factors. 2–6 However, the future of cancer survivorship research must focus on novel approaches to identify, prevent, and mitigate adverse effects of cancer therapy. Attention should also be paid to disseminate and implement uniform and cost-effective patient-centered survivorship care within diverse clinical settings. In order to do this, future research priorities must include multi-disciplinary and internationally collaborative approaches to better understand the toxicity of novel agents, contribution of genetic factors and aging to late effects, targets for intervention, and the role of health services research and implementation science to assure universal access to evidence-based and comprehensive survivorship care.
登录
查看更多内容
影响因子：
3.2
作者：
Hudson, Melissa M.;Ness, Kirsten K.;Nolan, Vikki G.;Armstrong, Gregory T.;Green, Daniel M.;Morris, E. Brannon;Spunt, Sheri L.;Metzger, Monika L.;Krull, Kevin R.;Klosky, James L.;Srivastava, Deo Kumar;Robison, Leslie L.
通讯作者：
Robison, Leslie L.
影响因子：
45.3
作者：
Hudson, Melissa M.;Leisenring, Wendy;Cox, Cheryl L.
通讯作者：
Cox, Cheryl L.
影响因子：
45.3
作者：
Armstrong, Gregory T.;Kawashima, Toana;Oeffinger, Kevin C.
通讯作者：
Oeffinger, Kevin C.
影响因子：
10.3
作者：
Chen, Yan;Chow, Eric J.;Yasui, Yutaka
通讯作者：
Yasui, Yutaka
影响因子：
4.5
作者：
Cline, Melissa S.;Liao, Rachel G.;Tavtigian, Sean
通讯作者：
Tavtigian, Sean