Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort study.
Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort study.
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DOI：
10.1002/pbc.22875
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发表时间：
2011-05
影响因子：
3.2
通讯作者：
Robison, Leslie L.
中科院分区：
文献类型：
--
作者：
Hudson, Melissa M.;Ness, Kirsten K.;Nolan, Vikki G.;Armstrong, Gregory T.;Green, Daniel M.;Morris, E. Brannon;Spunt, Sheri L.;Metzger, Monika L.;Krull, Kevin R.;Klosky, James L.;Srivastava, Deo Kumar;Robison, Leslie L.
为了便于对在儿童恶性肿瘤中幸存的成人进行前瞻性医学评估，并促进对儿童癌症长期幸存者健康的了解，圣裘德儿童研究医院(SJCRH)正在建立一个终身幸存者队列。纳入圣犹大终身队列研究的资格标准包括：1)在圣裘德癌症医院接受治疗的儿童恶性肿瘤的诊断；2)确诊后10年的生存≥；以及3)当前年龄≥18岁。参与分为三个层次：1)对SJCRH校园的综合评估；2)有限的家庭评估；或3)仅完成健康调查。一个系统的招募结构，以50名患者为基础，最初侧重于白血病和淋巴瘤幸存者以及符合试点研究条件的患者。截至2010年1月1日，已联系了3,900名符合条件的≥10年幸存者中的1,625人(42%)。在最初1000名可能符合条件的幸存者中，971人随后被确认符合资格标准。到目前为止，已成功联系898/971人(92.5%)，其中825人(91.8%)同意参加。在参与者中，88.6%的人同意综合医学评估，0.4%的人同意有限的局部评估，11.0%的人只同意调查。预计最低总体医学评价参与率为75.3%(731/971)。比较那些同意参与和拒绝参与的人，发现拒绝参与的男性比例更高(p=0.001)。SJLIFE研究的早期结果支持其招募老年儿童癌症幸存者参加通过医学评估评估晚期健康结果的研究调查的可行性。
To facilitate prospective medical assessment of adults surviving pediatric malignancies and advance knowledge about long-term childhood cancer survivor health, St. Jude Children’s Research Hospital (SJCRH) is establishing a lifetime cohort of survivors. Eligibility criteria for inclusion in the St. Jude Lifetime Cohort (SJLIFE) study include: 1) diagnosis of childhood malignancy treated at SJCRH; 2) survival ≥ 10 years from diagnosis; and 3) current age ≥ 18 years. Three levels of participation are offered: 1) comprehensive evaluation on SJCRH campus; 2) limited home evaluation; or 3) completion of health surveys only. A systematic recruitment structure based upon blocks of 50 patients initially focused on leukemia and lymphoma survivors and patients eligible for pilot studies. As of 01/01/2010, 1625 (42%) of 3900 eligible ≥ 10 year survivors have been contacted. Among the first 1000 potentially eligible survivors selected for recruitment, 971 were subsequently confirmed to fulfill eligibility criteria. To date, 898/971 (92.5%) have been successfully contacted of whom 825 (91.8%) have agreed to participate. Among participants, 88.6% agreed to comprehensive medical evaluation, 0.4% limited local evaluation, and 11.0% survey only. Anticipated minimum overall participation rate for medical evaluation is 75.3% (731/971). Comparison of those contacted who agreed versus declined to participate revealed a greater proportion of males who declined participation (p = 0.001). Early results of the SJLIFE study support its feasibility to recruit aging childhood cancer survivors to research investigations evaluating late health outcomes by medical assessments.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
4.8
作者：
Chemaitilly, W.;Boulad, F.;Sklar, C. A.
通讯作者：
Sklar, C. A.
影响因子：
45.3
作者：
Garmey, Edward G.;Liu, Qi;Oeffinger, Kevin C.
通讯作者：
Oeffinger, Kevin C.
DOI：
10.1177/1043454204264388
发表时间：
2004-05-01
期刊：
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
影响因子：
--
作者：
Hudson, Melissa M;Hester, Allison;Kaplan, Stuart
通讯作者：
Kaplan, Stuart
影响因子：
6.2
作者：
Meacham, LR;Gurney, JG;Oeffinger, KC
通讯作者：
Oeffinger, KC