New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain.
New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain.
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DOI：
10.1146/annurev-neuro-061010-113708
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发表时间：
2016-07-08
影响因子：
13.9
通讯作者：
Dulac C
中科院分区：
文献类型：
--
作者：
Perez JD;Rubinstein ND;Dulac C
哺乳动物的进化需要在基因调控方面进行多种创新，包括基因组印记的出现，这是一种表观遗传调控，导致基因从其母系或父系等位基因中优先表达。基因组印记在大脑中非常普遍，然而，直到最近，它在神经过程中的核心作用还没有得到充分的认识。在这里，我们提供了一个全面的调查成年和发育的大脑功能的印记基因的影响，从神经发育和布线突触功能和可塑性，能量平衡，社会行为，情感和认知。我们进一步审查了广泛的识别父母的偏见旁边的脑组织中的单等位基因表达，讨论其潜在的作用，在剂量调节的关键神经通路，并提出可能的机制，在大脑中的动态调节的印记。这篇综述有助于更好地理解基因组印记在包括人类在内的哺乳动物的正常和病理大脑中的意义。
Mammalian evolution entailed multiple innovations in gene regulation, including the emergence of genomic imprinting, an epigenetic regulation leading to the preferential expression of a gene from its maternal or paternal allele. Genomic imprinting is highly prevalent in the brain, yet, until recently, its central roles in neural processes have not been fully appreciated. Here, we provide a comprehensive survey of adult and developmental brain functions influenced by imprinted genes, from neural development and wiring to synaptic function and plasticity, energy balance, social behaviors, emotions, and cognition. We further review the widespread identification of parental biases alongside monoallelic expression in brain tissues, discuss their potential roles in dosage regulation of key neural pathways, and suggest possible mechanisms underlying the dynamic regulation of imprinting in the brain. This review should help provide a better understanding of the significance of genomic imprinting in the normal and pathological brain of mammals including humans.
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由印记基因MKRN3突变引起的中央早熟青春期。
DOI：
10.1056/nejmoa1302160
发表时间：
2013-06-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Abreu AP;Dauber A;Macedo DB;Noel SD;Brito VN;Gill JC;Cukier P;Thompson IR;Navarro VM;Gagliardi PC;Rodrigues T;Kochi C;Longui CA;Beckers D;de Zegher F;Montenegro LR;Mendonca BB;Carroll RS;Hirschhorn JN;Latronico AC;Kaiser UB
通讯作者：
Kaiser UB
影响因子：
2.5
作者：
Batassa, Enrico Maria;Costanzi, Marco;Cestari, Vincenzo
通讯作者：
Cestari, Vincenzo
影响因子：
2
作者：
Bittel, Douglas C.;Kibiryeva, Nataliya;White, Robert A.
通讯作者：
White, Robert A.
影响因子：
64.5
作者：
Ahuja, Rashmi;Pinyol, Roser;Qualmann, Britta
通讯作者：
Qualmann, Britta
影响因子：
3.7
作者：
Bando, Yuki;Hirano, Tomoo;Tagawa, Yoshiaki
通讯作者：
Tagawa, Yoshiaki