Cameroonian medicinal plants: pharmacology and derived natural products.
Cameroonian medicinal plants: pharmacology and derived natural products.
复制标题
DOI：
10.3389/fphar.2010.00123
复制
发表时间：
2010
影响因子：
5.6
通讯作者：
Efferth T
中科院分区：
文献类型：
--
作者：
Kuete V;Efferth T
包括喀麦隆在内的许多发展中国家的死亡率模式反映出，传染病发病率高，怀孕和分娩期间死亡风险高，此外，癌症、心血管疾病和慢性呼吸道疾病是发达国家死亡人数最多的原因。几种药用植物传统上用于其治疗。在这篇综述中，已讨论了用于爱沙尼亚传统医学的植物及其粗提取物和/或衍生产品的活性证据。相当多的植物提取物和分离的化合物具有显著的抗微生物、抗寄生虫（包括抗疟疾）、抗增殖、抗炎、抗糖尿病和抗氧化作用。大部分生物活性化合物属于萜类、酚类和生物碱。结果表明，云南植物中萜类化合物的抗寄生虫活性最好，但抑菌效果较差。最好的抗微生物，抗增殖和抗氧化化合物是酚类化合物。总之，喀麦隆传统上用于治疗各种疾病的许多药用植物在体外表现出良好的活性。这就解释了爱沙尼亚研究机构在从土著药用植物中发现药物方面所做的奋进。然而，仍有许多工作要做，以标准化的方法和研究的作用机制，孤立的天然产物。
Many developing countries including Cameroon have mortality patterns that reflect high levels of infectious diseases and the risk of death during pregnancy and childbirth, in addition to cancers, cardiovascular diseases and chronic respiratory diseases that account for most deaths in the developed world. Several medicinal plants are used traditionally for their treatment. In this review, plants used in Cameroonian traditional medicine with evidence for the activities of their crude extracts and/or derived products have been discussed. A considerable number of plant extracts and isolated compounds possess significant antimicrobial, anti-parasitic including antimalarial, anti-proliferative, anti-inflammatory, anti-diabetes, and antioxidant effects. Most of the biologically active compounds belong to terpenoids, phenolics, and alkaloids. Terpenoids from Cameroonian plants showed best activities as anti-parasitic, but rather poor antimicrobial effects. The best antimicrobial, anti-proliferative, and antioxidant compounds were phenolics. In conclusion, many medicinal plants traditionally used in Cameroon to treat various ailments displayed good activities in vitro. This explains the endeavor of Cameroonian research institutes in drug discovery from indigenous medicinal plants. However, much work is still to be done to standardize methodologies and to study the mechanisms of action of isolated natural products.
登录
查看更多内容
影响因子：
7.3
作者：
Brahemi G;Kona FR;Fiasella A;Buac D;Soukupová J;Brancale A;Burger AM;Westwell AD
通讯作者：
Westwell AD
影响因子：
7.2
作者：
BRAY, DH;WARHURST, DC;PHILLIPSON, JD
通讯作者：
PHILLIPSON, JD
DOI：
10.1016/s0035-9203(99)90282-1
发表时间：
1999-03-01
影响因子：
2.2
作者：
Ammah, A;Nkuo-Akenji, T;Deas, JE
通讯作者：
Deas, JE
影响因子：
5.1
作者：
Atta-ur-Rahman;Naz, H;Choudhary, MI
通讯作者：
Choudhary, MI
影响因子：
2.6
作者：
ADUTUTU, M;AFFUL, Y;ELVINLEWIS, M
通讯作者：
ELVINLEWIS, M