TRPV channels and vascular function.
TRPV channels and vascular function.
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DOI：
10.1111/j.1748-1716.2010.02217.x
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Brayden JE
中科院分区：
文献类型：
--
作者：
Baylie RL;Brayden JE
香草素亚型(TRPV)的瞬时受体电位通道作为感觉介质，被内源性配体、热、机械和渗透应激所激活。在血管内，TRPV通道表达于血管周围神经、血管内皮细胞和血管内皮细胞。它们的不同分布和多模式激活特性使其非常适合于调节血管功能、感知和响应局部环境变化的作用。在内皮细胞中，TRPV1被内源性大麻素激活，TRPV3被饮食激动剂激活，TRPV4被剪切力、环氧二十碳三烯酸(EETs)激活，并在GQ偶联受体激活的下游。激活后，这些通道通过一氧化氮(NO)、前列环素(PGI2)和中/小电导钾通道(IKCa/SKCa)依赖的途径促进血管扩张。在血管内皮细胞中，TRPV4被内皮来源的EETs激活，导致大电导钾通道(BKCa)激活和平滑肌超极化。相反，平滑的TRPV2通道有助于钙离子的全球进入，并可能有助于收缩。TRPV1和TRPV4在感觉神经中表达，可通过释放CGRP和P物质引起血管扩张，并通过压力感受性反射(TRPV1)或渗透应激时交感神经流出增加(TRPV4)介导血管功能。因此，TRPV通道在调节血管系统中正常和病理的细胞功能方面发挥着重要作用。
Transient receptor potential channels, of the vanilloid subtype (TRPV), act as sensory mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress. Within the vasculature, TRPV channels are expressed in smooth muscle cells, endothelial cells, as well as in peri-vascular nerves. Their varied distribution and polymodal activation properties make them ideally suited to a role in modulating vascular function, perceiving and responding to local environmental changes. In endothelial cells, TRPV1 is activated by endocannabinoids, TRPV3 by dietary agonists, and TRPV4 by shear stress, epoxyeicosatrienoic acids (EETs), and downstream of Gq-coupled receptor activation. Upon activation, these channels contribute to vasodilation via nitric oxide (NO), prostacyclin (PGI2), and intermediate/small conductance potassium channel (IKCa/SKCa) dependent pathways. In smooth muscle, TRPV4 is activated by endothelial derived EETs, leading to large conductance potassium channel (BKCa) activation and smooth muscle hyperpolarization. Conversely, smooth muscle TRPV2 channels contribute to global calcium entry and may aid constriction. TRPV1 and TRPV4 are expressed in sensory nerves and can cause vasodilation through CGRP and substance P release as well as mediating vascular function via the baroreceptor reflex (TRPV1) or via increasing sympathetic outflow during osmotic stress (TRPV4). Thus, TRPV channels play important roles in the regulation of normal and pathological cellular function in the vasculature.
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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影响因子：
4.8
作者：
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