Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization.
Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization.
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DOI：
10.1002/eji.201546262
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发表时间：
2016-07
影响因子：
5.4
通讯作者：
Chaikof, Elliot L.
中科院分区：
文献类型：
--
作者：
Angsana, Julianty;Chen, Jiaxuan;Liu, Liying;Haller, Carolyn A.;Chaikof, Elliot L.
已经提出了胞效作用促进依赖于运动性和迁移的巨噬细胞消退程序，然而，很少有研究涉及消退巨噬细胞中的定向迁移。在这份报告中，我们假设红细胞增多症会诱导差异趋化因子受体表达。极化的巨噬细胞群体，包括积极参与巨噬细胞，其特征在于通过PCR阵列和传统的transwell运动分析。我们确定了小鼠和人巨噬细胞上趋化因子受体CXCR4的特异性上调，并在小鼠腹膜炎消退模型中表征了CXCR4的体内表达。采用过继转移和AMD3100阻断，我们证实了CXCR4在巨噬细胞排出引流管中的作用。总的来说，这些数据提供了巨噬细胞增多和巨噬细胞迁移之间的重要机制联系。
Efferocytosis has been suggested to promote macrophage resolution programs that are dependent on motility and emigration, however, few studies have addressed directed migration in resolving macrophages. In this report, we hypothesized that efferocytosis would induce differential chemokine receptor expression. Polarized macrophage populations, including macrophages actively engaged in efferocytosis, were characterized by PCR array and traditional transwell motility assays. We identified specific up-regulation of chemokine receptor CXCR4 on both mouse and human macrophages and characterized in vivo expression of CXCR4 in a resolving model of murine peritonitis. Using adoptive transfer and AMD3100 blocking, we confirmed a role for CXCR4 in macrophage egress to draining lymphatics. Collectively these data provide an important mechanistic link between efferocytosis and macrophage emigration.
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影响因子：
5.4
作者：
Schif-Zuck, Sagie;Gross, Nufar;Assi, Simaan;Rostoker, Ran;Serhan, Charles N.;Ariel, Amiram
通讯作者：
Ariel, Amiram
影响因子：
20.3
作者：
Gautier, Emmanuel L.;Ivanov, Stoyan;Randolph, Gwendalyn J.
通讯作者：
Randolph, Gwendalyn J.
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
影响因子：
2.8
作者：
Kolaczkowska, Elzbieta;Koziol, Agnieszka;Arnold, Bernd
通讯作者：
Arnold, Bernd
DOI：
10.1161/atvbaha.114.304650
发表时间：
2015-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Thomas G;Tacke R;Hedrick CC;Hanna RN
通讯作者：
Hanna RN