Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2.
Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2.
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播散性坏疽性脓皮病：血管内皮生长因子和缺氧诱导因子 2 的作用。
DOI：
10.1016/j.jaad.2009.02.033
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发表时间：
2009
影响因子：
13.8
通讯作者：
Arbiser,JackL
中科院分区：
文献类型：
--
作者：
Chua,RamonAlvin;Mackelfresh,Jamie;Cohen,Cynthia;Varma,Vijay;Fried,Levi;Arbiser,JackL
坏疽性脓皮病（PG）是炎症和肿瘤性疾病的常见表现。临床上，这些病变表现为愈合极其缓慢的深溃疡。它可以发生在内脏和内脏1。这些病变可能是由于阻止炎症正常消退的缺陷所致。PG没有普遍有效的治疗方法。该患者有一个异常严重的PG病例，累及内脏和皮肤。为了深入了解PG的信号传导过程，我们分析了血管内皮生长因子（VEGF）和血管生成素-2（Ang-2）的产生，以及这些分子上游的转录因子，缺氧诱导因子2-α（HIF 2a）。然后我们对另外3例患者的其他样本进行染色，以确定我们的发现是否可以推广到PG。在所有病变中观察到VEGF和HIF 2a的高水平表达。PG病变中Ang-2灶性阳性
Pyoderma gangrenosum (PG) is a common manifestation of inflammatory and neoplastic disorders. Clinically, these lesions appear as deep ulcers that are extremely slow to heal. It may occur cutaneously as well as viscerally 1. These lesions may be due to defects that prevent normal resolution of inflammation. No universally effective therapy exists for PG.The index patient had an unusually severe case of PG, involving viscera as well as skin. In order to gain insight into the signaling processes underlying PG, we analyzed the production of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2), as well as a transcription factor upstream of these molecules, hypoxia inducible factor 2-alpha (HIF2a). We then stained additional samples from 3 additional patients to determine whether our findings can be generalized to PG. High level expression of VEGF and HIF2a was observed in all lesions. Ang-2 was focally positive in PG lesions
顽固性坏疽性脓皮病：沙利度胺治疗。
影响因子：
13.8
作者：
Melanie S. Hecker;M. Lebwohl
通讯作者：
M. Lebwohl
影响因子：
6.5
作者：
Perry, Betsy N.;Govindarajan, Baskaran;Arbiser, Jack L.
通讯作者：
Arbiser, Jack L.
患有坏疽性脓皮病的青少年出现空洞性肺部浸润：一种罕见的中性粒细胞性皮肤病的皮外表现。
影响因子：
13.8
作者：
Timothy S. Brown;Gary S. Marshall;J. P. Callen
通讯作者：
J. P. Callen