Brain structural changes and the development of interference control in children with ADHD: The predictive value of physical activity and body mass index.
Brain structural changes and the development of interference control in children with ADHD: The predictive value of physical activity and body mass index.
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DOI：
10.1016/j.nicl.2022.103141
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发表时间：
2022
影响因子：
4.2
通讯作者：
Ishihara, Toru
中科院分区：
文献类型：
--
作者：
Ludyga, Sebastian;Ishihara, Toru
患有多动症的儿童在青春期前表现出干扰控制的缺陷。灰质比异常导致这些缺陷。较高的体力活动和较低的身体质量指数预示着较高的干扰控制。灰质比是体质指数预测价值的基础。大脑结构不能解释体育活动的预测价值。由于大脑结构异常，多动症儿童在干扰控制方面存在缺陷。低体重指数和高体力活动是促进大脑健康的因素，可能有可能减少adhd相关的认知缺陷。我们的目的是研究ADHD、体重指数和身体活动对干扰控制的预测价值，以及大脑结构对这些关联的潜在中介作用。在9岁和11岁时，来自abcd队列的4576名ADHD儿童和神经正常的同龄人完成了侧卫任务、人体测量评估和报告的身体活动。此外，在两个测量时间点采集T1和t2加权磁共振图像。ADHD、较低的体力活动和较高的基线体重指数预示着较低的干扰控制。灰质体积、表面积和灰质白质比对干扰控制有贡献。身体质量指数与干扰控制之间的纵向关联是由灰质比介导的。这种中介效应在ADHD儿童中强于神经正常的同龄人，并且主要局限于与认知控制相关的区域。维持较低的身体质量指数有助于通过使灰质比的局部改变正常化的趋势来控制干扰。服从体育活动也承诺更高的干扰控制，但大脑结构似乎并不是这种联系的基础。
Children with ADHD show deficits in interference control during preadolescence. Abnormalities in gray-white matter ratio contributed contribute to these deficits. Higher physical activity and lower body mass index predict higher interference control. Gray-white matter ratio underlies the predictive value of body mass index. Brain structure does not explain the predictive value of physical activity. Children with ADHD face deficits in interference control due to abnormalities in brain structure. A low body mass index and high physical activity are factors promoting brain health and may have the potential to reduce ADHD-related cognitive deficits. We aimed to investigate the predictive values of ADHD, body mass index and physical activity for interference control and the potential mediation of these associations by brain structure. At 9 and 11 years, 4576 children with ADHD and neurotypical peers from the ABCD-cohort completed a Flanker task, anthropometric assessments and reported physical activity. Additionally, T1- and T2-weighted magnet resonance images were collected at both measurement time points. ADHD, lower physical activity and higher body mass index at baseline predicted lower interference control. Gray matter volume, surface area and gray-white matter ratio contributed to interference control. The longitudinal association between body mass index and interference control was mediated by gray-white-matter ratio. This mediating effect was stronger for children with ADHD than neurotypical peers and mainly restricted to regions associated with cognitive control. The maintenance of a lower body mass index contributes to interference control by a tendency to normalize regional alterations in grey-white-matter ratio. Being compliant with physical activity also promises higher interference control, but brain structure does not seem to underlie this association.
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影响因子：
17.7
作者：
Hoogman, Martine;Muetzel, Ryan;Franke, Barbara
通讯作者：
Franke, Barbara
影响因子：
1.5
作者：
Barkley, Russell A.;Fischer, Mariellen
通讯作者：
Fischer, Mariellen
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
DOI：
10.1080/15374416.2017.1417860
发表时间：
2018-03
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
--
作者：
Danielson ML;Bitsko RH;Ghandour RM;Holbrook JR;Kogan MD;Blumberg SJ
通讯作者：
Blumberg SJ
影响因子：
4.7
作者：
Barch DM;Albaugh MD;Avenevoli S;Chang L;Clark DB;Glantz MD;Hudziak JJ;Jernigan TL;Tapert SF;Yurgelun-Todd D;Alia-Klein N;Potter AS;Paulus MP;Prouty D;Zucker RA;Sher KJ
通讯作者：
Sher KJ