Migraine Symptoms Improvement During the COVID-19 Lockdown in a Cohort of Children and Adolescents.
Migraine Symptoms Improvement During the COVID-19 Lockdown in a Cohort of Children and Adolescents.
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DOI：
10.3389/fneur.2020.579047
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发表时间：
2020
影响因子：
3.4
通讯作者：
Borgatti R
中科院分区：
文献类型：
--
作者：
Dallavalle G;Pezzotti E;Provenzi L;Toni F;Carpani A;Borgatti R
背景：儿童偏头痛是儿童最常见的原发性或共病性神经系统疾病之一。心理压力源被广泛认为是儿童偏头痛反复发作的潜在诱因。鉴于COVID-19紧急情况可能影响了儿童和青少年偏头痛患者的压力水平，本研究旨在了解COVID-19紧急情况对儿科患者症状强度和频率的影响。方法：在帕维亚（意大利）的IRCCS Mondino基金会儿童神经病学和精神病学部门登记了142名诊断为偏头痛的儿童和青少年患者。从医疗记录中获得社会人口统计学和临床特征。通过在线调查收集新冠肺炎暴露情况、封锁期间的压力反应、COVID-19紧急情况下的焦虑症状以及封锁前和期间偏头痛症状的强度和频率等信息。结果：门诊患者占绝大多数（125例，占88.0%），有先兆偏头痛52例（36.6%），无先兆偏头痛90例（63.4%）。所有在COVID-19之前报告症状恶化进展的患者在封锁期间强度均有所降低（χ2 = 31.05, p < 0.0001）。在封锁前症状恶化的患者中，有50%、病情稳定的患者中有45%、病情已经好转的患者中有12%出现症状频率减少。所有在COVID-19之前症状缓解的患者在封锁期间病情稳定（χ2 = 38.66, p < 0.0001）。焦虑症状与偏头痛发作频率显著相关（χ2 = 19.69, p < 0.001）。分别对有和没有先兆的个体重复分析并不影响结果，并且在两个患者亚组中都证实了显著的关联。讨论：在意大利北部的COVID-19封锁阶段，观察到儿科患者偏头痛症状的强度和频率显著降低。在封锁前病情稳定或恶化的患者中，偏头痛症状的强度和频率的改善尤为显著。在环境挑战和压力减少期间，症状严重程度的减轻进一步突出了为这些患者提供压力调节和应对方面的有效培训的必要性。
Background: Pediatric migraine is among the most common primary or comorbid neurologic disorders in children. Psychological stressors are widely acknowledged as potential triggers involved in recurring episodes of pediatric migraine. As the COVID-19 emergency may have affected the levels of stress perceived by children and adolescents with migraine, the present study was aimed to understand the effect of COVID-19 emergency on symptoms intensity and frequency in pediatric patients. Methods: A cohort of 142 child and adolescent patients with a diagnosis of migraine was enrolled at the Child Neurology and Psychiatry Unit of the IRCCS Mondino Foundation in Pavia (Italy). Socio-demographic and clinical characteristics were obtained from medical records. An on-line survey was used to collect information on COVID-19 exposure, stress response to the lockdown period, anxious symptoms during COVID-19 emergency, as well as migraine symptoms intensity and frequency before and during the lockdown. Results: The great majority were outpatients (n = 125, 88.0%), 52 (36.6%) had migraine with aura, whereas, 90 (63.4%) had migraine without aura. All the patients reporting worsening symptoms progression before COVID-19, had reduced intensity during the lockdown (χ2 = 31.05, p < 0.0001). Symptoms frequency reduction was observed in 50% of patients presenting worsening symptoms before the lockdown, 45% of those who were stable, and 12% of those who were already improving. All patients who had resolved symptoms before COVID-19 were stable during the lockdown (χ2 = 38.66, p < 0.0001). Anxious symptomatology was significantly associated with greater migraine symptoms frequency (χ2 = 19.69, p < 0.001). Repeating the analysis separately for individuals with and without aura did not affect the findings and significant associations were confirmed for both the patients' subgroups. Discussion: A significant reduction of migraine symptoms intensity and frequency was observed in pediatric patients during the COVID-19 lockdown phase in northern Italy. The improvement in both intensity and frequency of the migraine symptoms was especially significant in patients who were stable or worsening before the lockdown. The reduction of symptoms severity during a period of reduced environmental challenges and pressures further highlights the need of providing effective training in stress regulation and coping for these patients.
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影响因子：
3.8
作者：
Hjern, Anders;Alfven, Gosta;Ostberg, Viveca
通讯作者：
Ostberg, Viveca
影响因子：
3.6
作者：
Connelly, Mark;Bickel, Jennifer
通讯作者：
Bickel, Jennifer
影响因子：
3.7
作者：
Ashina, Sait;Bendtsen, Lars;Ashina, Messoud
通讯作者：
Ashina, Messoud
DOI：
10.1186/s10194-017-0780-8
发表时间：
2017-12
期刊：
The journal of headache and pain
影响因子：
--
作者：
Moon HJ;Seo JG;Park SP
通讯作者：
Park SP
影响因子：
4.9
作者：
Hagen, K;Vatten, L;Bovim, G
通讯作者：
Bovim, G