Neuroadaptations in adenosine receptor signaling following long-term ethanol exposure and withdrawal.
Neuroadaptations in adenosine receptor signaling following long-term ethanol exposure and withdrawal.
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DOI：
10.1111/j.1530-0277.2011.01586.x
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Prendergast MA
中科院分区：
文献类型：
--
作者：
Butler TR;Prendergast MA
乙醇影响神经递质系统的功能，导致改变神经兴奋性的神经适应。腺苷就是这样一种受体系统，它会被乙醇暴露所改变。目前的审查是集中在A1和A2A受体亚型的背景下，乙醇相关的神经适应性和乙醇戒断，因为这些亚型（i）激活的基础水平的腺苷，（ii）已被最充分的研究，他们的作用在神经保护和乙醇相关的现象，（iii）是主要网站的行动咖啡因在大脑中，一种物质通常与乙醇一起摄入。很明显，腺苷能信号的改变介导了急性乙醇给药的许多作用，特别是在运动功能和镇静方面。此外，长期乙醇暴露已被证明在细胞表面的表达或功能的A1和A2A受体亚型，影响，可能促进神经元兴奋性在乙醇戒断过程中产生的适应。作为一个整体，这些研究结果表明，乙醇诱导的适应腺苷受体信号可能影响神经元功能，活力，酒精摄入量的复发后禁欲的显着作用。
Ethanol affects the function of neurotransmitter systems, resulting in neuroadaptations that alter neural excitability. Adenosine is one such receptor system that is changed by ethanol exposure. The current review is focused on the A1 and the A2A receptor subtypes in the context of ethanol-related neuroadaptations and ethanol withdrawal because these subtypes (i) are activated by basal levels of adenosine, (ii) have been most well-studied for their role in neuroprotection and ethanol-related phenomena, and (iii) are the primary site of action for caffeine in the brain, a substance commonly ingested with ethanol. It is clear that alterations in adenosinergic signaling mediate many of the effects of acute ethanol administration, particularly with regard to motor function and sedation. Further, prolonged ethanol exposure has been shown to produce adaptations in the cell surface expression or function of both A1 and the A2A receptor subtypes, effects that likely promote neuronal excitability during ethanol withdrawal. As a whole, these findings demonstrate a significant role for ethanol-induced adaptations in adenosine receptor signaling that likely influence neuronal function, viability, and relapse to ethanol intake following abstinence.
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DOI：
10.1111/j.1742-7843.2004.pto950509.x
发表时间：
2004-12-01
影响因子：
3.1
作者：
Connole, L;Harkin, A;Maginn, M
通讯作者：
Maginn, M
DOI：
10.1111/j.1530-0277.1989.tb00338.x
发表时间：
1989-06-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
CLARK, M;DAR, MS
通讯作者：
DAR, MS
影响因子：
2.9
作者：
Dar, MS
通讯作者：
Dar, MS
影响因子：
2.9
作者：
CUNHA, RA;JOHANSSON, B;FREDHOLM, BB
通讯作者：
FREDHOLM, BB
影响因子：
1.7
作者：
Curry, Kim;Stasio, Michael J.
通讯作者：
Stasio, Michael J.