Reward circuitry function in autism during face anticipation and outcomes.
Reward circuitry function in autism during face anticipation and outcomes.
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DOI：
10.1007/s10803-011-1221-1
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发表时间：
2012-03
影响因子：
3.9
通讯作者：
Bodfish JW
中科院分区：
文献类型：
--
作者：
Dichter GS;Richey JA;Rittenberg AM;Sabatino A;Bodfish JW
本研究的目的是调查奖励电路的反应，在自闭症的奖励预期和结果的货币和社会奖励。在货币预期中，自闭症谱系障碍（ASD）的参与者在右侧丘脑核中表现出低激活，在右侧海马中表现出高激活，而在货币结果中，ASD的参与者在左侧额中回和前扣带回中表现出高激活。两组人的丘脑核对面孔的反应没有差异。ASD组在预测社会症状严重程度的面部预期过程中双侧杏仁核过度激活，在面部结果过程中双侧岛叶皮层过度激活。这些结果增加了越来越多的证据，证明自闭症的特征是奖励回路功能的改变。此外，在社会奖励过程中的非典型杏仁核激活可能有助于自闭症特征的发展或表达。
The aim of this study was to investigate reward circuitry responses in autism during reward anticipation and outcomes for monetary and social rewards. During monetary anticipation, participants with autism spectrum disorders (ASDs) showed hypoactivation in right nucleus accumbens and hyperactivation in right hippocampus, whereas during monetary outcomes, participants with ASDs showed hyperactivation in left midfrontal and anterior cingulate gyrus. Groups did not differ in nucleus accumbens responses to faces. The ASD group demonstrated hyperactivation in bilateral amygdala during face anticipation that predicted social symptom severity and in bilateral insular cortex during face outcomes. These results add to the growing body of evidence that autism is characterized by altered functioning of reward circuitry. Additionally, atypical amygdala activation during the processing of social rewards may contribute to the development or expression of autistic features.
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影响因子：
1.9
作者：
Canli, T;Zhao, Z;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1111/j.1749-6632.2010.05445.x
发表时间：
2010-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2010
影响因子：
--
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
3.9
作者：
Constantino, JN;Davis, SA;Reich, W
通讯作者：
Reich, W
DOI：
10.1073/pnas.0935845100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Carr, L;Iacoboni, M;Lenzi, GL
通讯作者：
Lenzi, GL