Weight variability, physical functioning and incident disability in older adults.
Weight variability, physical functioning and incident disability in older adults.
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DOI：
10.1002/jcsm.13239
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发表时间：
2023-08
期刊：
影响因子：
--
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中科院分区：
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本研究旨在确定身体质量指数（BMI）的较大变异性是否与老年人身体功能下降和意外残疾有关。包括来自健康、衰老和身体成分研究的参与者，他们在前3年随访期间有半年BMI数据。使用两种方法将参与者分为BMI变异性的五分之一。第一种方法使用平均连续变异性，而第二种方法调整这些值以消除3年期间BMI净变化引起的变异性。在研究的前3年期间，使用线性回归来评估BMI变异性的两个测量值与BMI、脂肪质量指数、非典型瘦体重指数和健康、衰老和身体成分身体表现评分的净变化之间的关系。考克斯比例风险模型用于评估BMI变异性与随后新发残疾发生率的关系，并对混杂因素进行调整。在2121名参与者中，BMI变异性最高的五分之一人群更有可能失去两个体重（β：−0.086 [95%置信区间，CI：−0.133，−0.040]，P < 0.01）和脂肪量（β：−0.059 [95%CI：−0.117，−0.002]，P = 0.04），体能评分下降幅度更大（β：−0.094 [95%CI：−0.162，−0.026]，P < 0.01）与BMI变异性最小的参与者相比。BMI变异性高的参与者也有较高的残疾发生率（风险比：1.36 [95% CI：1.07，1.72]，P = 0.01），与净BMI变化无关。老年人的BMI变异性与体能下降和意外残疾有关。这种关系不能仅仅用净体重减轻来解释，而是支持它作为脆弱的一个独立特征。
This study aimed to determine if greater variability in body mass index (BMI) is associated with declines in physical functioning and incident disability in older adults. Included were participants from the Health, Aging and Body Composition Study who had semi‐annual BMI data during the first 3 years of follow‐up. Participants were categorized into quintiles of BMI variability, using two methods. The first method used average successive variability, whereas the second method adjusted these values to remove the variability due to net change in BMI over the 3‐year period. Linear regression was used to assess the relationship between the two measures of BMI variability and net changes in BMI, fat mass index, appendicular lean mass index, and Health, Aging and Body Composition Physical Performance Score during the first 3 years of the study. Cox proportional hazard models were used to assess the relationship of BMI variability with the subsequent incidence of new disability, adjusting for confounding factors. Among 2121 participants, those in the highest BMI variability quintile were more likely to lose both body mass (β: −0.086 [95% confidence interval, CI: −0.133, −0.040], P < 0.01) and fat mass (β: −0.059 [95% CI: −0.117, −0.002], P = 0.04) and had greater declines in physical performance score (β: −0.094 [95% CI: −0.162, −0.026], P < 0.01) compared to participants with the least variability in BMI. Participants with high BMI variability also had higher rates of incident disability (hazard ratio: 1.36 [95% CI: 1.07, 1.72], P = 0.01), independent of net BMI change. BMI variability in older adults is associated with decline in physical performance and incident disability. This relationship cannot be explained by net weight loss alone, supporting it as an independent feature of frailty.
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DOI：
10.3803/enm.2021.1098
发表时间：
2021-08
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
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作者：
Jung I;Koo DJ;Lee MY;Moon SJ;Kwon H;Park SE;Rhee EJ;Lee WY
通讯作者：
Lee WY
DOI：
10.3233/jad-151172
发表时间：
2016-06-15
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Armstrong JJ;Godin J;Launer LJ;White LR;Mitnitski A;Rockwood K;Andrew MK
通讯作者：
Andrew MK
影响因子：
158.5
作者：
Bangalore, Sripal;Fayyad, Rana;Waters, David D.
通讯作者：
Waters, David D.
影响因子：
4.9
作者：
Ernsberger, P;Koletsky, RJ;Bedol, D
通讯作者：
Bedol, D
影响因子：
6.7
作者：
Perez-Tasigchana, Raul F.;Leon-Munoz, Luz M.;Guallar-Castillon, Pilar
通讯作者：
Guallar-Castillon, Pilar