Genomic discordance between monozygotic twins discordant for schizophrenia.
Genomic discordance between monozygotic twins discordant for schizophrenia.
复制标题
同卵双胞胎之间的基因组不一致与精神分裂症不一致。
DOI：
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发表时间：
1998
影响因子：
17.7
通讯作者：
Y. Okazaki
中科院分区：
文献类型：
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作者：
T. Tsujita;N. Niikawa;H. Yamashita;A. Imamura;A. Hamada;Y. Nakane;Y. Okazaki
OBJECTIVE
Genomic DNA of monozygotic twins discordant for schizophrenia was analyzed to determine whether their genomes were truly identical.
METHOD
The subjects were monozygotic male twins, one of whom had DSM-III-R schizophrenia, undifferentiated type. Genomic DNA was extracted from leukocytes and was applied to restriction landmark genome scanning analysis, which was developed for a high-speed survey of restriction sites throughout a genome and measurement of their copy number in each locus.
RESULTS
After comparisons of patterns with approximately 2,000 spots, the authors detected at least two spots with autoradiographic intensities that obviously differed in the two twins.
CONCLUSIONS
The discrepancies likely were generated either by differences in the methylation status at NotI sites between the twins or by submicroscopic changes occurring at NotI-flanking sites in one twin after (or simultaneous with) twinning. In either case, the difference may influence the transcription level of one or more genes.
使用限制性标志基因组扫描的扩展生产系统（RLGS Ver.1.8）绘制小鼠的遗传连锁图。
影响因子：
3.1
作者：
Okazaki,Y;Okuizumi,H;Sasaki,N;Ohsumi,T;Kuromitsu,J;Kataoka,H;Muramatsu,M;Iwadate,A;Hirota,N;Kitajima,M
通讯作者：
Kitajima,M