Gut microbiota is critical for the induction of chemotherapy-induced pain.
Gut microbiota is critical for the induction of chemotherapy-induced pain.
复制标题
肠道菌群对于诱导化学疗法诱导的疼痛至关重要。
DOI：
10.1038/nn.4606
复制
发表时间：
2017-09
影响因子：
25
通讯作者：
Mao J
中科院分区：
文献类型：
--
作者：
Shen S;Lim G;You Z;Ding W;Huang P;Ran C;Doheny J;Caravan P;Tate S;Hu K;Kim H;McCabe M;Huang B;Xie Z;Kwon D;Chen L;Mao J
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in those mice pretreated with antibiotics. Restoration of the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
登录
查看更多内容
影响因子：
--
作者：
Zhang, Xia;Goncalves, Ricardo;Mosser, David M
通讯作者：
Mosser, David M
影响因子：
7.4
作者：
Kielland, Anders;Blom, Thomas;Carlsen, Harald
通讯作者：
Carlsen, Harald
DOI：
10.1016/j.jpain.2016.02.011
发表时间：
2016-07
期刊：
The journal of pain
影响因子：
--
作者：
Zhang H;Li Y;de Carvalho-Barbosa M;Kavelaars A;Heijnen CJ;Albrecht PJ;Dougherty PM
通讯作者：
Dougherty PM
影响因子：
15.9
作者：
Kim, Hyangin;Chen, Lucy;Mao, Jianren
通讯作者：
Mao, Jianren
DOI：
10.1073/pnas.0711891105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Amaral, F. A.;Sachs, D.;Teixeira, M. M.
通讯作者：
Teixeira, M. M.