Animal models of fibrodysplasia ossificans progressiva.
Animal models of fibrodysplasia ossificans progressiva.
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DOI：
10.1002/dvdy.24606
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Yelick PC
中科院分区：
文献类型：
--
作者：
LaBonty M;Yelick PC
Fibrodysplasia Ossificans Progressiva is a rare human disease of heterotopic ossification. FOP patients experience progressive development of ectopic bone within fibrous tissues that contributes to a gradual loss of mobility and can lead to early mortality. Due to lack of understanding of the etiology and progression of human FOP, and the fact that surgical interventions often exacerbate FOP disease progression, alternative therapeutic methods are needed, including modeling in animals, to study and improve understanding of human FOP. In this review we provide an overview of the existing animal models of FOP and the key mechanistic findings from each. In addition, we highlight the specific advantages of a new adult zebrafish model, generated by our lab, to study human FOP.Developmental Dynamics 247:279–288, 2018. © 2017 Wiley Periodicals, Inc.
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DOI：
10.1002/jbmr.2820
发表时间：
2016-09
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Chakkalakal SA;Uchibe K;Convente MR;Zhang D;Economides AN;Kaplan FS;Pacifici M;Iwamoto M;Shore EM
通讯作者：
Shore EM
影响因子：
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通讯作者：
DERYNCK, R
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作者：
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通讯作者：
Shore, Eileen M.
影响因子：
4.8
作者：
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通讯作者：
Katagiri, Takenobu