Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome.
Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome.
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DOI：
10.1515/jpem-2012-0047
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Welt CK
中科院分区：
文献类型：
--
作者：
Carroll J;Saxena R;Welt CK
We hypothesized that BMI and DNA variants would predict age at menarche in PCOS. Subjects: Subjects with PCOS defined by the NIH criteria (n=522) and controls with regular menstrual cycles and no hyperandrogenism (n=472); aged 18 to 45 years were studied. Age at menarche was compared between PCOS cases and controls, and examined as a function of multiple parameters. There was a strong inverse relationship between BMI and age at menarche in PCOS (r=−0.32; p=5×10−11). The chromosome 6 rs7759938-T variant was associated with earlier age at menarche in women with PCOS (12.60±0.09 vs. 13.41±0.23 years; genotype TT vs. CC; p=0.006). Age at menarche was predicted by PCOS status (β=0.512; p<0.001), reported weight group at 10 to 14 years (β= −0.432; p<0.001), current BMI (β= −0.0202; p=0.01) and genotype (β=0.169; p=0.02). Age at menarche in women with PCOS is influenced by BMI and genetic variants near LIN28B. NCT00166569
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影响因子：
3.7
作者：
Ewens KG;Jones MR;Ankener W;Stewart DR;Urbanek M;Dunaif A;Legro RS;Chua A;Azziz R;Spielman RS;Goodarzi MO;Strauss JF 3rd
通讯作者：
Strauss JF 3rd
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
5
作者：
Must, A;Phillips, SM;Rand, WM
通讯作者：
Rand, WM
影响因子：
30.8
作者：
Sulem, Patrick;Gudbjartsson, Daniel F.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
120.7
作者：
Gillman, MW;Rifas-Shiman, SL;Colditz, GA
通讯作者：
Colditz, GA