Serum antibodies to nicotinic acetylcholine receptors in schizophrenic patients
Serum antibodies to nicotinic acetylcholine receptors in schizophrenic patients
复制标题
精神分裂症患者烟碱乙酰胆碱受体血清抗体
DOI：
10.1016/0920-9964(94)90070-1
复制
发表时间：
1994
影响因子：
4.5
通讯作者：
R. Reddy
中科院分区：
文献类型：
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作者：
S. Mukherjee;S. Mahadik;A. Korenovsky;Helio Laev;D. Schnur;R. Reddy
虽然血清烟碱乙酰胆碱受体（nAChR）的抗体水平升高已在抗精神病药治疗的迟发性运动障碍患者的报告，这样的抗体尚未确定在可比的非运动障碍患者。使用毒素结合抑制试验，我们检查了17个DSM-III-R慢性精神分裂症患者的血清抗nAChR抗体水平，其中7人有持续性迟发性运动障碍，和10名正常对照。平均而言，抗nAChR抗体水平显着高于精神分裂症患者比正常对照组，但没有迟发性运动障碍的患者之间的差异，并不涉及患者的年龄，性别，或病程。
Although elevated serum levels of antibodies to the nicotinic acetylcholine receptor (nAChR) have been reported in neuroleptic treated patients with tardive dyskinesia, such antibodies have not been determined in comparable nondyskinetic patients. Using a toxin-binding inhibition assay, we examined serum anti-nAChR antibody levels in 17 DSM-III-R chronic schizophrenic patients, seven of whom had persistent tardive dyskinesia, and 10 normal controls. On the average, anti-nAChR antibody levels were significantly higher in schizophrenic patients than in normal controls, but did not differ between patients with and without tardive dyskinesia, and was not related to age, sex, or duration of illness in patients.
影响因子：
--
作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
通讯作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
DOI：
10.1073/pnas.79.1.188
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
TZARTOS, SJ;SEYBOLD, ME;LINDSTROM, JM
通讯作者：
LINDSTROM, JM
几种退行性疾病中乙酰胆碱和尼古丁结合的减少。
影响因子：
--
作者：
Whitehouse,PJ;Martino,AM;Marcus,KA;Zweig,RM;Singer,HS;Price,DL;Kellar,KJ
通讯作者：
Kellar,KJ