EFFECTS OF GRF(1–40) AND DOMPERIDONE ON GH SECRETION IN NORMAL MAN
EFFECTS OF GRF(1–40) AND DOMPERIDONE ON GH SECRETION IN NORMAL MAN
复制标题
GRF(1–40) 和多潘立酮对正常人 GH 分泌的影响
DOI：
10.1111/j.1365-2265.1984.tb03220.x
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发表时间：
1984
影响因子：
3.2
通讯作者：
G. Giordano
中科院分区：
文献类型：
--
作者：
M. Giusti;G. Mazzocchi;P. Sessarego;D. Mignone;A. Lomeo;M. Monachesi;G. Giordano
研究了8例正常成年男性GRF后垂体分泌（1-40）的变化。GRF给药（50 μg i.v.）后，生长激素释放增加，在15 ~ 60 min之间达到峰值。对LH、FSH、PRL、TSH和ACTH分泌无影响。研究了多潘立酮（DOM） （5mg i.v./h）和GRF + DOM后GH和PRL的释放情况。DOM和GRF + DOM后PRL显著升高。与单独使用GRF的激素反应相比，在15-45分钟和120分钟时，GRF加DOM的GH释放更为显著（P < 0.05）。在研究的8个对象中，有6个发现了这种现象。GRF + DOM组的平均峰值和分泌面积均大于单独使用GRF组（P < 0.05）。这些数据表明，所使用剂量的GRF（1-40）是研究生长激素分泌的有用工具。GRF + DOM期间的生长激素模式似乎表明多巴胺能张力可能对人类生长激素分泌起直接抑制作用。
In eight normal adult men pituitary secretion following GRF(1–40) was studied. GRF administration (50 μg i.v.) was followed by an increase in GH release with a peak value between the 15 and 60 min. No effects were noticed on LH, FSH, PRL, TSH and ACTH secretion. GH and PRL release was also studied after domperidone (DOM) (5 mg i.v./h), and GRF plus DOM. PRL increased significantly after DOM and GRF plus DOM. During GRF plus DOM a more marked GH release was observed in comparison with the hormone response to GRF alone at 15–45 and 120 min (P < 005). This phenomenon was found in six out of eight subjects studied. Mean peak and secretory area was greater (P < 005) after GRF plus DOM than after GRF alone. These data suggest that GRF(1–40) at the dose used is a useful tool in the study of GH secretion. The GH pattern during GRF plus DOM seems to indicate that dopaminergic tone may play a direct inhibitory role on GH secretion in man.
人类血浆生长激素对生长激素释放因子反应的年龄相关变化。
DOI：
10.1210/jcem-58-1-212
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Shibasaki,T;Shizume,K;Nakahara,M;Masuda,A;Jibiki,K;Demura,H;Wakabayashi,I;Ling,N
通讯作者：
Ling,N
影响因子：
56.9
作者：
GUILLEMIN, R;BRAZEAU, P;WEHRENBERG, WB
通讯作者：
WEHRENBERG, WB